Alcohol and the Liver

1. Front Matter

   Pages i-ix

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2. The Epidemiology of Cirrhosis of the Liver: A Statistical Analysis of Mortality Data with Special Reference to Canada

   • W. Schmidt

   Pages 1-26

3. Discussion

   • J. G. Rankin

   Pages 27-30

4. Metabolism of Ethanol and the Effect of Ethanol on Metabolism

   • Frank Lundquist

   Pages 31-43

5. The Role of Ethanol Metabolites in Hepatic Lipid Peroxidation

   • N. R. Di Luzio, T. E. Stege

   Pages 45-62

6. Pyridine Nucleotides and Ethanol

   • Ellen R. Gordon

   Pages 63-77

7. The Influence of Ethanol on Albumin Metabolism

   • Marcus A. Rothschild, M. Oratz, S. S. Schreiber

   Pages 79-100

8. Mechanism of Induction by Ethanol of Hepatic Microsomal Drug Metabolizing Enzymes

   • Jean-Gil Joly, Jean-Pierre Villeneuve, P. Mavier, C. Hétu

   Pages 101-117

9. Acceleration of Ethanol Metabolism by High Ethanol Concentrations and Chronic Ethanol Consumption: Role of the Microsomal Ethanol Oxidizing System (MEOS)

   • Shohei Matsuzaki, R. Teschke, K. Ohnishi, C. S. Lieber

   Pages 119-143

10. Discussion

    • H. Kalant

    Pages 145-149

11. Metabolism of Ethanol and the Effects of Ethanol on Metabolism: General Discussion

    • M. M. Fisher

    Pages 151-165

12. Organelle Pathology of Alcohol-Induced Hepatic Injury

    • Emanuel Rubin, Arthur I. Cederbaum

    Pages 167-193

13. Discussion

    • M. J. Phillips

    Pages 195-196

14. Pathogenesis of Alcoholic Liver Disease: An Overview

    • C. S. Lieber

    Pages 197-255

15. Discussion

    • K. J. Isselbacher

    Pages 257-259

16. Alcoholic Hepatitis

    • S. W. French, J. S. Sim, K. E. Franks, E. J. Burbige, T. Denton, M. G. Caldwell

    Pages 261-286

17. Discussion

    • K. J. Isselbacher

    Pages 287-288

18. The Pathogenesis of Alcoholic Cirrhosis

    • Hans Popper

    Pages 289-305

19. Discussion

    • K. J. Isselbacher

    Pages 307-307

20. Immune Mechanisms in Alcoholic Liver Disease

    • Roy A. Fox

    Pages 309-320

Alcohol abuse is this culture's most important drug problem. Statistics indicate that it is exacting a great and relentlessly increasing toll of human suffering. It is clear that the problem is not being dealt with in any effective manner. At the invitation of the. Canadian Hepatic Foundation, many of the world's experts gathered in Toronto, May 14-15 1976, to focus attention on one of the most important aspects of the alcohol problem -alcohol induced liver damage. The epidemiology of alcohol induced liver disease was discussed and current views on the pathogenesis of the problem were reviewed. New insight into the pathological alterations of the liver was presented and some of our current therapeutic capabilities were discussed. Dr. Hans Popper summarized the Symposium and presented some of his views on those aspects of the problem which will require early attention by the research community. The Symposium achieved its immediate objective -that of bringing together the committed experts of various disciplines for an updating of our understanding of alcohol and the liver and for a discussion of new approaches to the problem. As a backdrop to the Symposium, however, was large writing on the wall to the effect that we are expending our research talents and efforts on a totally unnecessary problem. Right now we probably know enough and have sufficient resources at our disposal to solve the problem.

• alcohol
• attention
• cirrhosis
• drug
• epidemiology
• hepatitis
• liver
• liver disease
• pathogenesis
• research
• statistics

• University of Toronto, Toronto, Canada

  M. M. Fisher

• Addiction Research Foundation, Toronto, Canada

  J. G. Rankin

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