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The Pathogenesis of Alcoholic Cirrhosis

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Alcohol and the Liver

Abstract

A discussion of the pathogenesis of alcoholic cirrhosis must 1) define cirrhosis to identify the lesion, 2) describe the forms in ethanol abusers, 3) most important, trace the developmental pathways, of possible significance in rational management, 4) enumerate diagnostic criteria, important in management since alcohol withdrawal can arrest the disorder, and 5) indicate the relation to carcinoma.

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References

  1. POPPER H, ORR W: Current concepts in cirrhosis. Scand J Gastroenterol 6: 203–222, 1970

    CAS  Google Scholar 

  2. GROSS G, BABEL JF, RITSCHARD J, MEGEVAND R, ROHNER A, DONATH A, PERRIER CV: Quantification of intrahepatic porta- systemic shunting in cirrhotic patients: Possible relevance to the problem of indication for surgical procedure. In The Liver, Quantitative Aspects of Structure and Function. R Preisig, J Bircher, G Paumgartner, (eds.). Aulendorf, Editio Cantor, 1976. pp. 159–166

    Google Scholar 

  3. SHALDON S, CHIANDUSSI L, GUEVARA L, CAESAR J, SHERLOCK S: The estimation of hepatic blood flow and intrahepatic shunted blood flow by colloidal heat-denatured human serum albumin labeled with I131. J Clin Invest 40: 1346–1354, 1961

    Article  PubMed  CAS  Google Scholar 

  4. PREISIG R, BIRCHER J, PAUMGARTNER G: Physiologic and patho physiologic aspects of the hepatic hemodynamics. In Progress in Liver Diseases, vol IV. H Popper, F Schaffner, (eds.). New York, Grune <5r Stratton, 1972. pp. 201–216

    Google Scholar 

  5. GALAMBOS JT: Classification of cirrhosis. Am J Gastroenterol 64: 437–451, 1975

    PubMed  CAS  Google Scholar 

  6. MEISTER HP, SZANTO PB, SCHOOLMAN H: Quantitative-morphologic evaluation of postnecrotic cirrhosis. Virchows Arch Pathol Anat 336: 447–464, 1963

    Article  CAS  Google Scholar 

  7. GALL EA: Posthepatitic, postnecrotic and nutritional cirrhosis: a pathological analysis. Am J Pathol 36: 241–259, 1960

    PubMed  CAS  Google Scholar 

  8. STEINER PE: Precision in the classification of cirrhosis of the liver. Am J Pathol 37: 21–47, 1960

    PubMed  CAS  Google Scholar 

  9. RUBIN E, KRUS S, POPPER H: Pathogenesis of postnecrotic cirrhosis in alcoholics. Arch Pathol 73: 288–298, 1962

    PubMed  CAS  Google Scholar 

  10. POPPER H, RUBIN E, KRUS S, SCHAFFNER F: Postnecrotic cirrhosis in alcoholics. Gastroenterol 39: 669–685, 1960

    CAS  Google Scholar 

  11. LEE FI: Cirrhosis and hepatoma in alcoholics. Gut 7: 77–85, 1966

    Article  PubMed  CAS  Google Scholar 

  12. GERBER MA, POPPER H: Relation between central canals and portal tracts in alcoholic hepatitis. A contribution to the pathogenesis of cirrhosis in alcoholics. Human Pathol 3: 199–107, 1972

    Article  CAS  Google Scholar 

  13. RUBIN E, POPPER H: The evolution of human cirrhosis deduced from observations in experimental animals. Medicine 46: 163–183, 1967

    Article  PubMed  CAS  Google Scholar 

  14. POPPER H, ELIAS H: Histogenesis of hepatic cirrhosis studied by the three-dimensional approach. Am J Pathol 31: 405–441, 1955

    PubMed  CAS  Google Scholar 

  15. GERBER MA, ORR W, DENK H, SCHAFFNER F, POPPER H: Hepatocellular hyalin in cholestasis and cirrhosis: Its diagnostic significance. Gastroenterol 64: 89–98, 1973

    CAS  Google Scholar 

  16. POPPER J, UDENFRIEND S: Hepatic fibrosis - correlation of biochemical and morphologic investigations. Am J Med 49: 707- 721, 1970

    Article  PubMed  CAS  Google Scholar 

  17. RAPPAPORT AM: The microcirculatory hepatic unit. In Drugs and the Liver. W Gerok, K Sickinger, (eds.). Stuttgart, FK Schattauer Verlag, 1975. pp. 425–434

    Google Scholar 

  18. RAPPAPORT AM: The microcirculatory hepatic unit. Microvasc Res 6: 212–228, 1973

    Article  PubMed  CAS  Google Scholar 

  19. KENT G, FELS IG, DUBIN A, POPPER H: Collagen content based on hydroxyproline determinations in human and rat livers. Its relation to morphologically demonstrable reticulum and collagen fibers. Lab Invest 8: 48–56, 1959

    PubMed  CAS  Google Scholar 

  20. Collagen Metabolism in the Liver. H Popper, K Becker, (eds.). New York, Stratton Intercontinental Medical Book Corporation, 1975

    Google Scholar 

  21. MILLER EJ, MATUKAS VJ: Biosynthesis of collagen. The biochemist's view. FedProc 33: 1197–1204, 1974

    CAS  Google Scholar 

  22. HAHN E, TIMPL R, MILLER EJ: Demonstration of a unique antigenic specificity for the collagen alpha-1 (II) chain from cartilaginous tissue. Immunology 28: 1–8, 1975

    Google Scholar 

  23. HAHN E, TIMPL R, MILLER EJ: The production of specific antibodies to native collagens with the chain composition (alpha-l(I)A (alpha- 1(II)3) and (alpha-l(I)2). J Immunol 113: 421–423, 1974

    PubMed  CAS  Google Scholar 

  24. WOLMAN M: Polarized light microscopy as a tool of diagnostic pathology. J Histochem Cytochem 23: 21–50, 1975

    Article  PubMed  CAS  Google Scholar 

  25. ROSS R: The connective tissue fiber forming cell. In Treatise on Collagen vol. 2. GN Ramachandran, BS Gould, (eds). New York, Academic Press, 1968

    Google Scholar 

  26. LANGNESS U, UDENFRIEND S: Collagen biosynthesis of nonfibro- blastic cell lines. Proc Nat Acad Sci 71: 50–51, 1974

    Article  PubMed  CAS  Google Scholar 

  27. STERN R. Personal communication.

    Google Scholar 

  28. BRONFENMAJOR S, SCHAFFNER F, POPPER H: Fat-storing cells (lipocytes) in human liver. Arch Pathol 82: 447–453, 1966

    Google Scholar 

  29. ITO T: Recent advances in the study on the fine structure of the hepatic sinusoidal wall; A review. Gunma Rep Med Sci 6: 119- 163, 1973

    Google Scholar 

  30. POPPER H: Distribution of vitamin A in tissue as visualized by fluorescence microscopy. Physiol Rev 24: 205–224, 1944

    CAS  Google Scholar 

  31. KOBAYASHI K, TAKAHASHI Y, SHIBASAKI S: Cytological studies of fat-storing cells in the liver of rats given large doses of vitamin A. Nature New Biol 243: 186–188, 1973

    PubMed  CAS  Google Scholar 

  32. SCHNACK H, STOCKINGER L, WEWALKA F: Adventitious connective tissue cells in the space of Disse and their relation to fiber formation. Rev Int Hepat 17: 855–860, 1967

    PubMed  CAS  Google Scholar 

  33. TANIKAWA K: Ultrastructure of hepatic fibrosis and fat-storing cells. In Collagen Metabolism in the Liver. H Popper, K Becker, (eds.). New York, Stratton Intercontinental Medical Book Corporation, 1975. pp. 93–99

    Google Scholar 

  34. KENT G, BAHU R, INOUYE T, MINICK T, POPPER H: The role of the Ito cell (lipocyte) in hepatic injury. Gastroenterol 69: A35/835, 1975

    Google Scholar 

  35. GAY S, FIETZEK PP, REMBERGER K, EDER M, KUHN K: Liver cirrhosis: Immunofluorescence and biochemical studies demonstrate two types of collagen. Klin Wschr 53: 205–208, 1975

    Article  PubMed  CAS  Google Scholar 

  36. REMBERGER K, GAY S, FIETZEK PP: Immunhistochemische Unter suchungen zur Kollagencharakterisierung in Lebercirrhosen. Virchows Arch A Pathol Anat Histol 367: 231–240, 1975

    Article  PubMed  CAS  Google Scholar 

  37. ROJKIND M, MARTINEZ- PALOMO A: Increase in type I and type III collagens in human alcoholic liver cirrhosis. Proc Nat Acad Sci USA 73: 539–543, 1976

    Article  PubMed  CAS  Google Scholar 

  38. EDMONDSON HA, PETERS RL, REYNOLDS TB, KUZMA OT: Sclero sing hyaline necrosis of the liver in the chronic alcoholic: a recognizable syndrome. Ann Int Med 59: 646–673, 1963

    PubMed  CAS  Google Scholar 

  39. POPPER H, SZANTO PB, ELIAS H: Transition of fatty liver into cirrhosis. Gastroenterol 28: 183–192, 1955

    CAS  Google Scholar 

  40. POPPER H, SZANTO PB, PARTHASARATHY M: Florid cirrhosis. Am J Clin Pathol 15: 889–901, 1955

    Google Scholar 

  41. FEINMAN L, LIEBER CS: Fibrogenic effect of alcohol in rat liver: Role of diet. Science 179: 406–407, 1973

    Article  Google Scholar 

  42. GALAMBOS JT: Collagen metabolism in chronic alcoholic liver injury. In Alcohol and the Liver. W Gerok, K Sickinger, HH Hennekeuser, (eds). Stuttgart, FK Schattauer Verlag, 1971. pp. 321–331

    Google Scholar 

  43. CHEN TS, LEEVY CM: Collagen biosynthesis in liver disease of the alcoholic. J Lab Clin Med 85: 103–112, 1975

    PubMed  CAS  Google Scholar 

  44. MEZEY E, POTTER JJ, MADDREY WC: Collagen turnover in alcoholic liver disease. Gastroenterol 65: A-36/560, 1973

    Google Scholar 

  45. POPPER H, SCHAFFNER F: Hepatic cirrhosis, a problem in communic ations. Israel J Med Sci 4: 1–7, 1968

    CAS  Google Scholar 

  46. LEITNER ZA, MOORE T, SHARMAN IM: Fatal self-medication with retinol and carrot juice. Proc Nutr Soc 34: 44A, 1975

    Google Scholar 

  47. POPPER H, SCHAFFNER F: Nutritional cirrhosis in man? New Eng J Med 285: 577–578, 1971

    Article  PubMed  CAS  Google Scholar 

  48. THALER H: Relation of steatosis to cirrhosis. In Clinics in Gastroenterology. H Popper, (ed.). London, WB Saunders Company Ltd, 1975. pp. 273–280

    Google Scholar 

  49. MCDONALD RA: Primary carcinoma of the liver. Arch Intern Med 99: 266–279, 1975

    Google Scholar 

  50. FISHER RL, SCHEUER PJ, SHERLOCK S: Primary liver cell carcinoma: Alcohol and chronic liver disease. Gastroenterol 67: A-14/791, 1974

    Google Scholar 

  51. HALLEN H, LINNE I Cirrhosis of the liver in one community. A study of 768 cases of liver cirrhosis from a eity with one hospital: incidence, etiology and prognosis. In Alcoholic Cirrhosis and Other Toxic Hepatopathias. Skandia International Symposia. A Engel, T Larsson, (eds.). Stockholm, Nordiska Bokhandelns Forlag, 1970. pp. 336–352

    Google Scholar 

  52. ANTHONY PP, VOGEL CL, BARKER LF: Liver cell dysplasia; a premalignant condition. J Clin Pathol 26: 217–223, 1973

    Article  PubMed  CAS  Google Scholar 

  53. FARBER E: Pathogenesis of liver cancer. Arch Pathol 98: 145–148, 1974

    PubMed  CAS  Google Scholar 

  54. POPPER H, STERNBERG SS, OSER BL, OSER M: The carcinogenic effect of Aramite in rats. A study of hepatic nodules. Cancer 13: 1035–1045, 1960

    Article  PubMed  CAS  Google Scholar 

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© 1977 Plenum Press, New York

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Popper, H. (1977). The Pathogenesis of Alcoholic Cirrhosis. In: Fisher, M.M., Rankin, J.G. (eds) Alcohol and the Liver. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4184-0_17

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  • DOI: https://doi.org/10.1007/978-1-4613-4184-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4186-4

  • Online ISBN: 978-1-4613-4184-0

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