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The pharmacology of diuretics

  • Chapter
Cardiac therapy

Abstract

The development of a variety of diuretic drugs during the past several decades has been a major advance in the therapy of cardiac failure and other states characterized by edema formation. Diuretics are drugs which increase urine volume. Most diuretics used clinically directly inhibit the renal tubular reabsorption of sodium and chloride resulting in the excretion of a greater fraction of the glomerular filtrate into the urine. Other agents (which will not be discussed in this chapter) increase urinary volume by increasing the renal blood flow and the glomerular filtration rate or by inhibiting the tubular reabsorption of water.

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References

  1. Grantham JJ, Chonko AM: The physiological basis and clinical use of diuretics. In: Brenner BM, Stein JH (eds) Sodium and Water Homeostasis, vol 1. Churchill Livingston, New York, 1978, pp 178–211.

    Google Scholar 

  2. Burg M: The renal handling of sodium chloride. In: Brenner BM, Rector FC Jr (eds) The Kidney, vol I. Saunders, Philadelphia, 1976, pp 272–298.

    Google Scholar 

  3. Cannon PJ: The kidney in heart failure. N Engl J Med 296:26–32, 1977.

    PubMed  CAS  Google Scholar 

  4. Gottschalk GW, Lassiter WE, Mylle M: Localization of urine acidification in the mammalian kidney. Am J Physiol 98:581–585, 1960.

    Google Scholar 

  5. Giebisch G: The proximal nephron. In: Andreoli TE, Hoffman JF, Fanestil DD (eds) Physiology of Membrane Disorders. Plenum Publ, New York, 1978, p 629.

    Google Scholar 

  6. Earley L, Schrier, R: Intrarenal control of sodium excretion by hemodynamic and physical factors. In: Berne RM (ed) Handbook of Physiology. Section 8: Renal Physiology. Am Physiol Soc, Bethesda, 1973, pp 721–762.

    Google Scholar 

  7. Brenner B, Troy J, Daugherty T, MacInnes R: Quantitative importance of changes in post-glomerular colloid osmotic pressure in mediating glomerular tubular balance in the rat. J Clin Invest 52:190–197, 1973.

    PubMed  CAS  Google Scholar 

  8. Kokko J: Proximal tubule potential difference. Dependence on glucose, HCO3 and amino acids. J Clin Invest 52:1362–1367, 1973.

    PubMed  CAS  Google Scholar 

  9. Rector FC, Martinez-Maldonado M, Brenner FP, Seldin W: Evidence of passive reabsorption of sodium chloride in the proximal tubule of rat kidney. J Clin Invest 45:1060, 1966.

    Google Scholar 

  10. Imai M, Kokko JP: Sodium chloride urea and water transport in the thin ascending limb of Henle. J Clin Invest 53:383–402, 1974.

    Google Scholar 

  11. Burg MB, Stephenson JL: Transport characteristics of the loop of Henle. In: Andreoli TE, Hoffman JF, Fanestil DD (eds) Physiology of Membrane Disorders. Plenum Publ, New York, 1978, pp 661–679.

    Google Scholar 

  12. Burg MB, Green N: Function of the thick ascending limb of Henle’s loop. Am J Physiol 224:659–668, 1973.

    PubMed  CAS  Google Scholar 

  13. Rocha AS, Kokko JP: Sodum chloride and water transport in the thick ascending limb of Henle. Evidence for active chloride transport. J Clin Invest 52:612–623, 1973.

    PubMed  CAS  Google Scholar 

  14. Burg MB, Stoner L: Renal tubular chloride transport and mode of action of some diuretics. Ann Rev Physiol 38:37–45, 1976.

    CAS  Google Scholar 

  15. Windhager EE, Constanzo LS: Transport functions of the distal convoluted tubule. In: Andreoli TE, Hoffman JF, Fanestil DD (eds) Physiology of Membrane Disorders. Plenum Publ, New York, 1978, pp 681–706.

    Google Scholar 

  16. Shafer JA, Andreoli TE: The collecting duct. In: Andreoli TE, Hoffman JK, Fanestil DD (eds) Physiology of Membrane Disorders. Plenum Publ, New York, 1978, pp 707–737.

    Google Scholar 

  17. Stein JH, Reineck HJ: The role of the collecting duct in the regulation of excretion of sodium and other electrolytes. Kidney Int 6:1–9, 1974.

    PubMed  CAS  Google Scholar 

  18. Osgood RW, Reineck HJ, Stein JH: Further studies on segmental sodium transport in the rat kidney during expansion of the extracellular fluid volume. J Clin Invest 62:311–320, 1978.

    PubMed  CAS  Google Scholar 

  19. Giebisch G: Effects of diuretics on renal transport of potassium. In: Martinez-Maldonado M (ed) Methods in Pharmacology, vol 4A. Plenum Publ, New York, 1976, pp 121–164.

    Google Scholar 

  20. Maren TH: Carbonic anhydrase chemistry, physiology and inhibition. Physiol Rev 47:595–781, 1967.

    PubMed  CAS  Google Scholar 

  21. Grantham JJ, Chonka M: The physiological basis and clinical use of diuretics. In: Brenner BM, Stein JH (eds) Sodium and Water Homeostasis, vol 1. Churchill Livingston, New York, 1978, pp 178–211.

    Google Scholar 

  22. Kunau R, Weller D, Webb H: Clarification of the site of action of chlorothiazide in the rat kidney. J Clin Invest 56:401–407, 1975.

    PubMed  CAS  Google Scholar 

  23. Kunau R: The influence of the carbonic anhydrase inhibitor benzolamide (C1–11 366) on the reabsorption of chloride. J Clin Invest 51:294–305, 1972.

    PubMed  CAS  Google Scholar 

  24. Chou S, Porush JG, Slater PA, Flombaum CD, Shafi T, Fein PA: Effects on acetazolamide on proximal tubule Cl, Na, HCO3 transport in normal and acidotic dogs during distal blockade. J Clin Invest 60:162–170, 1977.

    PubMed  CAS  Google Scholar 

  25. Rector FC Jr, Seldin DW, Roberts AD Jr, Smith JS: The role of plasma CO2 tension and carbonic anhydrase activity in the renal reabsorption of the bicarbonate. J Clin Invest 39:1706–1721, 1960.

    PubMed  CAS  Google Scholar 

  26. Schwartz WB, Wallace NM: Electrolyte equilibrium during mercurial diuresis. J Clin Invest 30:1089–1104, 1951.

    PubMed  CAS  Google Scholar 

  27. Axelrod DR, Pitts RF: The relationship of plasma pH and anion patterns to mercurial diuresis. J Clin Invest 31: 171–174, 1952.

    PubMed  CAS  Google Scholar 

  28. Burg MB, Green N: Effect of mersalyl on the thick ascending limb of Henle’s loop. Kidney Int 4:245–251, 1973.

    PubMed  CAS  Google Scholar 

  29. Wright FS: Intrarenal regulation of glomerular filtration rate. N Engl J Med 291:135–141, 1974.

    PubMed  CAS  Google Scholar 

  30. Evanson RL, Lockhart EA, Dirks JH: Effect of mercurial diuretics on tubular sodium and potassium transport in dogs. Am J Physiol 222:282–289, 1974.

    Google Scholar 

  31. Nigrovic V, Cafruny EJ: Renal concentration of citrate as a negative modulator of diuretic response to mercurials. Nature 247:381–383, 1974.

    PubMed  CAS  Google Scholar 

  32. Freeman RB, Maher JF, Schreiner GE, Mostofii FK: Renal tubular necrosis due to nephrotoxicity of organic mercurial diuretics. Ann Intern Med 57:34–43, 1962.

    PubMed  CAS  Google Scholar 

  33. Cannon PJ, Ames RP, Laragh JH: Methylene butyryl phenoxyacetic acid. Novel potent natriuretic and diuretic agent. J Am Med Assoc 185:854–863, 1963.

    CAS  Google Scholar 

  34. Cannon PJ, Heinemann HO, Stason WB, Laragh JH: Ethacrynic acid-effectiveness and mode of diuretic action in man. Circulation 31:5–18, 1965.

    PubMed  CAS  Google Scholar 

  35. Cannon PJ, Kilcoyne MM: Ethacrynic acid and furosemide. Renal pharmacology and clinical use. Prog Cardiovasc Dis 12:99–118, 1969.

    PubMed  CAS  Google Scholar 

  36. Birtch AG, Zakheim RM, Jones LG, Barger AC: Redistribution of renal blood flow produced by furosemide and ethacrynic acid. Circ Res 21:869–878, 1967.

    PubMed  CAS  Google Scholar 

  37. Clapp JR, Nottebohm GA, Robinson RR: Proximal site of action of ethacrynic acid: importance of filtration rate. Am J Physiol 220:1355–1360, 1976.

    Google Scholar 

  38. Goldberg M, McCurdy DK, Foltz EL, Bluemle LW Jr: Effects of ethacrynic acid (a new saluretic agent) on renal diluting and concentrating mechanisms: evidence for site of action in the loop of Henle. J Clin Invest 43:201–216, 1964.

    PubMed  CAS  Google Scholar 

  39. Burg M, Green N: Effect of ethacrynic acid on the thick ascending limb of Henle’s loop. Kidney Int 4:301–308, 1973.

    PubMed  CAS  Google Scholar 

  40. Case D, Gunther S, Cannon PJ: Ethacrynate-induced depression of respiration in transport systems and kidney mitochondria. Am J Physiol 224:769–780, 1973.

    PubMed  CAS  Google Scholar 

  41. Cannon PJ, Dell RB, Winters RW: Effects of diuretics on electrolyte and lactate gradients in dog kidney. J Lab Clin Med 72:192–203, 1968.

    PubMed  CAS  Google Scholar 

  42. Cannon PJ, Heinemann HO, Albert MS, Laragh JH, Winters RW: ‘Contraction’ alkalosis after diuresis of edematous patients with ethacrynic acid. Ann Intern Med 62: 979–990, 1965.

    PubMed  CAS  Google Scholar 

  43. Stason WB, Cannon PJ, Heinemann HO, Laragh JH: Furosemide, a clinical evaluation of its diuretic action. Circulation 34:910–920, 1966.

    PubMed  CAS  Google Scholar 

  44. Stein JH, Wilson CB, Kirkendall WM: Differences in the acute effects of furosemide and ethacrynic acid in man. J Lab Clin Med 71:654–665, 1968.

    PubMed  CAS  Google Scholar 

  45. Puschett JB, Goldberg M: The acute effects of furosemide on acid and electrolyte excretion in man. J Lab Clin Med 71:666–677, 1968.

    PubMed  CAS  Google Scholar 

  46. Hook JB, Williamson HE: Influence of probenecid and alterations in acid-balance on the saliuretic activity of furosemide. J Pharmacol Exp Ther 149:404–408, 1972.

    Google Scholar 

  47. Burke T, Robinson R, Clapp J: Determinants of the effect of furosemide on the proximal tubule. Kidney Int 1:12–18, 1972.

    PubMed  CAS  Google Scholar 

  48. Burg M, Stoner L, Cardinal J, Green N: Furosemide effect on isolated perfused tubules. Am J Physiol 225:119–124, 1973.

    PubMed  CAS  Google Scholar 

  49. Abramow M: Effects of ethacrynic acid on the isolated collecting tubule. J Clin Invest 53:796–804, 1974.

    PubMed  CAS  Google Scholar 

  50. Dikshit K, Vyden JD, Forrester JS, Swan HJC: Renal and extra renal hemodynamic effects of furosemide in congestive heart failure after myocardial infarction. N Engl J Med 291:135–141, 1974.

    Google Scholar 

  51. Weinman EJ, Eknoyan G, Suki WN; The influence of extracellular fluid balance on the tubular transport of uric acid. J Clin Invest 55:283–291, 1975.

    PubMed  CAS  Google Scholar 

  52. Engle JE, Steele TH: Variation of urate excretion with urine flow in normal man. Nephron 16:50–56, 1976.

    PubMed  CAS  Google Scholar 

  53. Muth RG: Diuretic response to furosemide in the presence of renal insufficiency. J Am Med Assoc 195:1066–1069, 1966.

    CAS  Google Scholar 

  54. Berman LB, Ebrahimi A: Experiences with furosemide in renal disease. Proc Soc Biol Med 118:333–346, 1965.

    CAS  Google Scholar 

  55. Maher J, Schreiner GF: Studies on ethacryinc acid in patients with refractory edema. Ann Intern Med 62:15–29, 1965.

    PubMed  CAS  Google Scholar 

  56. Schneider WJ, Becker EL: Acute transient hearing ions after ethacrynic acid therapy. Arch Intern Med 117:715–717, 1966.

    PubMed  CAS  Google Scholar 

  57. Ashbury MJ, Gatenby PB, O’Sullivan S, Bourke E: ‘Bumetanide’ potent new ‘loop’ diuretic. Br Med J 1:211–213, 1972.

    Google Scholar 

  58. Olesen KH, Sigurd B, Steiness E, Leth A: Bumetanide, a new potent diuretic. Acta Med Scand 193:119–131, 1973.

    PubMed  CAS  Google Scholar 

  59. Carriere S, Dandavino R: Bumetanide, a new loop diuretic. Clin Pharmacol Ther 20:424–438, 1976.

    PubMed  CAS  Google Scholar 

  60. Jayakumar S, Puschett JB: Study of the sites and mechanisms of action of bumetanide in man. J Pharmacol Exp Ther 201:251–258, 1977.

    PubMed  CAS  Google Scholar 

  61. Beyer K, Baer J: Physiologic basis for the action of newer diuretic agents. Pharmacol Rev 13:517–564, 1961.

    PubMed  CAS  Google Scholar 

  62. Pitts R, Kruch F, Lozano R, Taylor D, Heidenreich O, Kessler R: Studies on the mechanism of diuretic action of chlorothiazide. J Pharmacol Exp Ther 123:89–97, 1958.

    PubMed  CAS  Google Scholar 

  63. Heinemann HO, Demartini EE, Laragh JH: The effect of chlorothiazide on renal excretion of electrolytes and free water. Am J Med 26:853–861, 1959.

    PubMed  CAS  Google Scholar 

  64. Earley LE, Kahn M, Orloff J: Effects of infusions of chlorothiazide on urinary dilution and concentration in the dog. J Clin Invest 40:857–866, 1961.

    PubMed  CAS  Google Scholar 

  65. Edwards F, Baer P, Sutton R, Dirks J: Micropuncture study of diuretic effects on sodium and calcium reabsorption in the dog nephron. J Clin Invest 52:2418–2427, 1978.

    Google Scholar 

  66. Ullrich K, Baumann K, Loeschke K, Ramrich G, Stolte H: Micropuncture experiments with saluretic sulfonamides. Ann NY Acad Sci 139:416–423, 1966.

    PubMed  CAS  Google Scholar 

  67. Goldring RM, Cannon PJ, Heinemann HO, Fishman AP: Respiratory adjustment to chronic metabolic alkalosis in man. J Clin Invest 47:188–202, 1968.

    PubMed  CAS  Google Scholar 

  68. Earley L, Orloff J: The mechanism of antidiuresis associated with the administration of hydrochlorothiazide to patients with vasopressin-resistant diabetes mellitus. J Clin Invest 41:1988–1997, 1962.

    PubMed  CAS  Google Scholar 

  69. Lamberg BA, Kuhlback G: Effect of chlorothiazide and hydrochlorothiazide on the excretion of sodium in the urine. Scand J Clin Lab Invest 11:351–357, 1959.

    PubMed  CAS  Google Scholar 

  70. Costanzo LS, Windhager EE: Distal reabsorption of calcium: effect of load and chlorothiazide (CTZ). Fed Proc 35:466, 1976.

    Google Scholar 

  71. Brickman A, Wassry S, Coburn J: Changes in serum and urinary calcium during treatment with hydrochlorothiazide. J Clin Invest 51:945–954, 1972.

    PubMed  CAS  Google Scholar 

  72. Parfitt AM: The interactions of thiazide diuretics with parathyroid hormone and vitamin D. Studies in patients wiht hypoparathyroidism. J Clin Invest 51:1879–1888, 1972.

    PubMed  CAS  Google Scholar 

  73. Popoutzer MM, Subryan VL, Alfey AC, Reeve EB, Schrier RM: The acute effect of chlorothiazide on serum-ionized calcium: evidence for a parathyroid hormone-dependent mechanism. J Clin Invest 55:1295–1302, 1975.

    Google Scholar 

  74. DeMartini FE, Wheaton, EA, Healy LA, Laragh JH: Effect of chlorothiazide on renal excretion of uric acid. Am J Med 32:572–577, 1962.

    Google Scholar 

  75. Steele TH, Oppenheimer S: Factors affecting urate excretion following diuretic administration in man. Am J Med 47:564–574, 1969.

    PubMed  CAS  Google Scholar 

  76. Stote RM, Dubb JW, Familiar RG, Alexander F: Ticrynafen, a uricosuric antihypertensive diuretic. Clin Pharmacol 23:456–460, 1978.

    CAS  Google Scholar 

  77. Nemati M, Kyle MC, Fries ED: Clinical study of ticrynafen, a new diuretic antihypertensive and uricosuric agent. J Am Med Assoc 237:652–657, 1977.

    CAS  Google Scholar 

  78. Wood AJ, Bolli P, Waalanning HJ, Simpson FD: Ticrynafen: kinetics, protein binding, and effects on serum and urinary uric acid. Clin Pharmacol Ther 23:697–702, 1978.

    PubMed  CAS  Google Scholar 

  79. Beck P, Asseher AW: Clinical evaluating metolazone (zaroxolyn): a new quinazoline diuretic. Clin Trials J 8:13–18, 1971.

    Google Scholar 

  80. Steinmuller SR, Puschett JB: Effects of metolazone in man: comparison with chlorothiazide. Kidney Int 1:169–181, 1972.

    PubMed  CAS  Google Scholar 

  81. Fernandez PC, Puschett JB: Proximal tubular actions of metolazone and chlorothiazide. Am J Physiol 225:954–961, 1973.

    PubMed  CAS  Google Scholar 

  82. Bennett WM, Porter GA: Efficacy and safety of metolazone in renal failure and the nephrotic syndrome. J Clin Pharmacol 13:357–364, 1973.

    PubMed  CAS  Google Scholar 

  83. Sonnenblick EH, Cannon PJ, Laragh JH: The nature of the action of intravenous aldosterone: evidence for a role of the hormone in urinary dilution. J Clin Invest 40:903–913, 1961.

    PubMed  CAS  Google Scholar 

  84. Kagawa C, Sturterant F, VanArman C: Pharmacology of a new steroid that blocks salt activity of aldosterone and desoxycorticosterone. J Pharmacol Exp Ther 126:123–130, 1959.

    PubMed  CAS  Google Scholar 

  85. Liddle G: Specific and non-specific inhibiton of mineralocorticoid activity. Metabolism 10:1021–1030, 1961.

    CAS  Google Scholar 

  86. Coppage WS Jr, Liddle GW: Mode of action and clinical usefulness of aldosterone antagonists. Ann NY Acad Sci 88:815–821, 1960.

    PubMed  CAS  Google Scholar 

  87. Baba W, Tudhope G, Wilson G: Triampterene, a new diuretic drug. Br Med J 2:756–760, 1962.

    PubMed  CAS  Google Scholar 

  88. Crosley AP Jr, Ronquille LM, Strickland WH, Alexander F: ‘Triampterene’, a natriuretic agent. Preliminary observations in man. Ann Intern Med 56:241–251, 1962.

    PubMed  CAS  Google Scholar 

  89. Weibelhaus V, Weinstock J, Maass A, Brennan F, Sosnowski G, Larsen T: The diuretic and natriuretic activity of triampterene and several related pteridines in the rat. J Pharmacol Exp Ther 149:397–403, 1965.

    Google Scholar 

  90. Baba W, Lant A, Smith A, Townsend M, Wilson G: Pharmacological effects in animals and normal human subjects of the diuretic amiloride hydrochloride (MK-870). Clin Pharmacol Ther 9:318–327, 1968.

    PubMed  CAS  Google Scholar 

  91. Bull MD, Laragh JH: ‘Amiloride’ a potassium-sparing natriuretic agent. Circulation 37:45–53, 1968.

    PubMed  CAS  Google Scholar 

  92. Duarte CG, Chomety F, Giebisch G: Effect of amiloride, ouabain and furosemide on distal tubular function in the rat. Am J Physiol 221:632–640, 1972.

    Google Scholar 

  93. Bentley P: Amiloride, a potent inhibitor of sodium transport across toad bladder. J Physiol 195:317–330, 1968.

    PubMed  CAS  Google Scholar 

  94. Crabbe J: A hypothesis concerning the mode of action of amiloride and triampterene. Arch Intern Pharmacodyn Ther 173:474–477, 1968.

    CAS  Google Scholar 

  95. Stoner LC, Burg MB, Orloff J: Ion transport in cortical collecting tubule; effect of amiloride. Am J Physiol 227: 453–459, 1974.

    PubMed  CAS  Google Scholar 

  96. Greenblatt DJ, Koch-Weser J: Adverse reactions to spironolactone. J Am Med Assoc 225:40–43, 1973.

    CAS  Google Scholar 

  97. Schultze RG: Recent advances in the physiology and pathophysiology of potassium excretion. Arch Intern Med 131:885–897, 1973.

    PubMed  CAS  Google Scholar 

  98. Cohn JH, Franciosa JA: Vasodilator therapy of cardiac failure. N Engl J Med 297:27–31, 254–261, 1977.

    PubMed  CAS  Google Scholar 

  99. Iff N W, Flenley DC: Blood-gas exchange after furosemide in acute pulmonary edema. Lancet 1:616–618, 1971.

    PubMed  CAS  Google Scholar 

  100. Scheinman M, Brown M, Rapaport E: Hemodynamic effects of ethacrynic acid in patients with refractory acute left ventricular failure. Am J Med 50:291–296, 1971.

    PubMed  CAS  Google Scholar 

  101. Freis ED, Wanko A, Wilson IM, Parrish AE: Chlorothiazide in hypertensive and normotensive patients. Ann NY Acad Sci 71:450–455, 1958.

    PubMed  CAS  Google Scholar 

  102. Hollander W, Chobanian AV: Mode of action of chlorothiazide and mercurial diuretics as antihypertensive agents. J Clin Invest 37:902, 1958.

    Google Scholar 

  103. Wilson IM, Freis ED: Relationship between plasma and extracellular fluid volume depletion and antihypertensive effect of chlorothiazide. Circulation 20:1028–1036, 1959.

    PubMed  CAS  Google Scholar 

  104. Alexsandrow D, Wysznacka W, Gajewski J: Studies on mechanisms of hypertensive action of chlorothiazide. N Engl J Med 260:51–55, 1959.

    Google Scholar 

  105. Frolich ED, Schnaper HW, Wilson IM, Freis ED: Hemodynamic alterations in hypertensive patients due to chlorothiazide. N Engl J Med 262:1261–1263, 1960.

    Google Scholar 

  106. Conway J, Lauwers P: Hemodynamic and hypotensive effect of long-term treatment with hydrochlorothiazide. Circulation 21:21–27, 1960.

    PubMed  CAS  Google Scholar 

  107. Tarazi RC, Dustan HP, Frolich ED: Long-term thiazide in essential hypertension. Evidence for persistent alteration in plasma volume and renin activity. Circulation 41:709–717, 1970.

    PubMed  CAS  Google Scholar 

  108. Minuth AN, Terrell JB Jr, Suki WN: Acute renal failure in study of the course and prognosis of 104 patients and the role of furosemide. Am J Med Sci 271:317–324, 1976.

    PubMed  CAS  Google Scholar 

  109. Epstein ME, Schneider NS, Befeler B: Effect of intrarenal furosemide on renal function and intrarenal hemodynamics in acute renal failure. Am J Med 58:510–516, 1975.

    PubMed  CAS  Google Scholar 

  110. Suki WN, Yium JJ, VonMinden M, Saller-Herbert C, Ekkoyan G, Martinez Maldonado M: Acute treatment of hypercalcemia with furosemide. N Engl J Med 283:836–840, 1970.

    PubMed  CAS  Google Scholar 

  111. Yendt ER, Guay GF, Garcia DA: The use of thiazides in the prevention of renal calculi. Can Med Assoc J 102: 614–620, 1970.

    PubMed  CAS  Google Scholar 

  112. Crawford JD, Kennedy GC, Hill LE: Clinical results of treatment of diabetes insipidus with drugs of the chlorothiazide series. N Engl J Med 262:737–743, 1960.

    PubMed  CAS  Google Scholar 

  113. Bell NH, Schedl HP, Bartter FC: An explanation of abnormal water retention and hypoosmolality in congestive heart failure. Am J Med 36:351–360, 1964.

    PubMed  CAS  Google Scholar 

  114. Verney EV: Croonian lecture: the antidiuretic hormone and the factors which determine its release. Proc R Soc Lond (Series B) 135:25–106, 1947.

    CAS  Google Scholar 

  115. Kassirer JP, Berkman PM, Lawrenz DR, Schwartz WB: Critical role of chloride in the correction of hypokalemic alkalosis in man. Am J Med 38:172–189, 1965.

    PubMed  CAS  Google Scholar 

  116. Kassirer JP, Schwartz WB: Correction of metabolic alkalosis in man without repair of potassium deficiency. Am J Med 40:19–26, 1966.

    PubMed  CAS  Google Scholar 

  117. Berger L, Yu T: Renal function in gout. IV. An analysis of 524 gouty subjects including long-term follow-up studies. Am J Med 59:605–613, 1975.

    PubMed  CAS  Google Scholar 

  118. Breckenridge A, Welbern TA, Dollery CT, Fraser TR: Glucose tolerance in patients on long-term diuretic therapy. Lancet 1:61–64, 1967.

    PubMed  CAS  Google Scholar 

  119. Glodner MG, Zarowitz H, Akgun F: Hyperglycemia and glucosuria due to thiazide derivatives administered in diabetes mellitus. N Engl J Med 262:403–405, 1960.

    Google Scholar 

  120. Loreauz L, Menard R, Taylor A, Patpita JC, Sauten R: Spironolactone and endocrine dysfunction. Ann Intern Med 85:630–636, 1976.

    Google Scholar 

  121. Potter H, Destaing F, Chauve L: Potentialization de l’effet des anticoagulants coumariniques por l’acid tienilique: use nouvelle observation. Nouv Presse Med 6:468, 1977.

    Google Scholar 

  122. Ames RP, Hill P: Elevation of serum lipids during diuretic therapy of hypertension. Am J Med 61:748–757, 1976.

    PubMed  CAS  Google Scholar 

  123. Freis E, et al: Study group on antihypertensive agents. Effects of treatment in morbidity in hypertension. J Am Med Assoc 202:1028–1034, 1967; 213:1143–1152, 1970.

    Google Scholar 

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  1. Columbia University, New York, USA

    Michael R. Rosen M.D.  & Brian F. Hoffman M.D.  & 

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© 1983 Martinus Nijhoff Publishers, Boston, The Hague, Dordrecht, Lancaster

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Cannon, P.J. (1983). The pharmacology of diuretics. In: Rosen, M.R., Hoffman, B.F. (eds) Cardiac therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3855-0_12

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  • DOI: https://doi.org/10.1007/978-1-4613-3855-0_12

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