Cardiac therapy

1. Front Matter

   Pages I-X

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2. Pathophysiology

   1. Electrophysiologic determinants of normal cardiac rhythms and arrhythmias

      • Michael R. Rosen, Brian F. Hoffman

      Pages 1-19

   2. Cardiac failure

      • William W. Parmley

      Pages 21-44

   3. Myocardial ischemia

      • John Ross Jr.

      Pages 45-71

3. Cardiac Autonomic Interactions and their Pharmacologic Modification

   1. Neural control of cardiac rhythm and contraction

      • Matthew N. Levy

      Pages 73-94

   2. Cholinergic agonists and antagonists

      • August M. Watanabe

      Pages 95-144

   3. Alpha- and beta-adrenergic agonists and antagonists

      • John A. Oates, David Robertson, Alastair J. J. Wood, Raymond L. Woosley

      Pages 145-169

4. Therapy of Cardiac Arrhythmias

   1. Pharmacology of the antiarrhythmic drugs

      • Penelope A. Boyden, Andrew L. Wit

      Pages 171-234

   2. Clinical use of antiarrhythmic drugs

      • Leonard S. Gettes, James R. Foster, Ross J. Simpson Jr.

      Pages 235-298

   3. Cardiac pacing: role in diagnosis and treatment of disorders of cardiac rhythm and conduction

      • Albert L. Waldo

      Pages 299-336

   4. Surgical therapy of arrhythmias

      • Mark E. Josephson, Alden H. Harken

      Pages 337-385

5. Therapy of Cardiac Failure and Ischemia

   1. The pharmacology of cardiac glycosides

      • Brian F. Hoffman

      Pages 387-412

   2. The pharmacology of diuretics

      • Paul J. Cannon

      Pages 413-434

   3. The pharmacolgy of vasodilator and antianginal drugs

      • Alan S. Nies, Gwynne Neufeld

      Pages 435-451

   4. Treatment of cardiac failure

      • Eric S. Williams, Charles Fisch

      Pages 453-479

   5. Medical management of ischemic heart disease

      • David W. Snyder, Burton E. Sobel

      Pages 481-535

   6. Cardiac surgical therapy of atherosclerosis and angina

      • Richard O. Russell Jr., Charles E. Rackley, Nicholas T. Kouchoukos

      Pages 537-550

6. Back Matter

   Pages 551-568

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Cardiac therapy has become ever more complex during the past quarter century. For example, 25 years ago, the therapy of cardiac failure was largely limited to digitalis, a very few diuretics, salt restriction, and general supportive measures. Antiarrhythmic therapy involved - in the main - quinidine, procainamide, and digitalis, and questions such as which arrhythmia to treat and how to measure drug efficacy had been addressed in elementary fashion only. Cardiac surgery was limited largely to congenital and valvular heart disease; the areas of cardiac pacemaker therapy, defibrillation and other forms of electrical diagnosis and therapy were rudimentary. The expansion of support of cardiovascular research by the National Institutes of Health as well as by institutional sources following World War II has led to major successes in clinical health care delivery and improved technology made available to clinical investigators. In reviewing progress over the past 25 years, we have been particularly impressed by one observation: this is the important interaction that has developed between studies of pathophysiology and the delivery of appropriate cardiac therapy.

• arrhythmia
• atherosclerosis
• cardiovascular
• drugs
• heart
• heart disease
• physiology

• Columbia University, New York, USA

  Michael R. Rosen, Brian F. Hoffman

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