Abstract
The first systematic description of the use of digitalis was provided in 1785 by William Withering in his book An Account of the Foxglove and Some of its Medical Uses: With Practical Remarks on Dropsy and Other Diseases. Since that time digitalis has been used to treat a variety of illnesses including most forms of edema. In more recent times digitalis was used first to treat atrial fibrillation and then it was used to treat what we would now accept as heart failure. There have been a great many studies on the pharmacology of digitalis, but in spite of this it still is a frequent subject for investigation and there probably is much we still need to learn about its actions and mechanisms of action.
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Hoffman, B.F. (1983). The pharmacology of cardiac glycosides. In: Rosen, M.R., Hoffman, B.F. (eds) Cardiac therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3855-0_11
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