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Metabolic studies of acute-phase proteins

  • Chapter
Pathophysiology of Plasma Protein Metabolism

Abstract

A variety of injuries to the animal organism elicit the common local and systemic reaction known as inflammation. This term covers many pathological phenomena, some of which are listed in figure 11.1 (for review see references 1–3). Drastic changes in the plasma concentration of some proteins, occurring during the acute-phase response, represent both a useful marker of the severity of the inflammation and an interesting model for studying regulatory mechanisms in protein metabolism. The concept of acute-phase proteins (AP proteins), defined as trauma-inducible liver-produced plasma glycoproteins4, has been expanded in recent years to include newly identified proteins, to elucidate control of their biosynthesis, and to delineate their biological functions and diagnostic or prognostic significance. Since the responses of individual plasma proteins to tissue injury vary considerably in a single organism (e.g. haptoglobin-transferrin) and since homologous proteins in closely related species may show different responses (e.g. serum amyloid P component in the rat and mouse), the general term ‘acute-phase react ant’ is rather vague.

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  1. CNR Institute of Clinical Physiology, Fifth Medical Pathology of the University of Pisa, Pisa, Italy

    Giuliano Mariani

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Koj, A. (1984). Metabolic studies of acute-phase proteins. In: Mariani, G. (eds) Pathophysiology of Plasma Protein Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2793-6_11

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  • DOI: https://doi.org/10.1007/978-1-4613-2793-6_11

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