Pathophysiology of Plasma Protein Metabolism

1. Front Matter

   Pages i-xiv

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2. Large models in the study of protein metabolism

   • L. Zech, M. Berman

   Pages 1-14

3. Optimal experiment design in plasma protein metabolic studies: Sequential, optimal sampling schedules for quantifying kinetics

   • J. J. DiStefano III

   Pages 15-34

4. Formulation, identification and validation of mathematical models for plasma protein metabolic studies

   • D. G. Cramp, E. R. Carson, C. Cobelli

   Pages 35-70

5. Kinetic modelling for distribution and removal of plasma proteins with altered biological behaviour in vivo

   • F. Vitek, G. Mariani, R. Bianchi

   Pages 71-86

6. Regulation of the interstitial distribution of plasma proteins

   • Victor M. Rosenoer, E. B. Reeve

   Pages 87-120

7. In vivo and in vitro regulation of albumin synthesis

   • M. A. Rothschild, M. Oratz, S. S. Schreiber

   Pages 121-139

8. In vitro and in vivo regulation of immunoglobulin synthesis

   • T. A. Waldmann

   Pages 141-149

9. IgA immunoglobulin synthesis, catabolism and transport

   • W. Strober, H. Kawanishi

   Pages 151-172

10. Regulation of retained and secreted liver proteins

    • H. Glaumann

    Pages 173-193

11. Metabolism of radiolabelled complement proteins in health and disease

    • C. A. Alper, F. S. Rosen

    Pages 195-220

12. Metabolic studies of acute-phase proteins

    • A. Koj

    Pages 221-248

13. Significance of in vivo and in vitro metabolic studies of tumour-produced proteins

    • G. Mariani, P. W. Sullivan, E. A. McGuire, K. R. Mclntire, R. H. Adamson, T. A. Waldmann

    Pages 249-263

14. Fibrinogen and fibrinogen-related peptides in cancer

    • J. J. Franks, R. E. Kirsch, Betty Kao, T. M. Kloppel

    Pages 265-278

15. Studies of antithrombin turnover

    • E. B. Reeve, R. D. Bies, B. D. Leonard, A. Stephens

    Pages 279-298

16. Nutritional aspects of plasma protein metabolic studies: Protein-energy malnutrition

    • P. G. Lunn

    Pages 299-323

17. Nutritional aspects of plasma protein metabolic studies: Long-term treatment of chronic uraemia by a very-low-protein diet supplemented with essential amino acids and keto analogues

    • G. Mariani, G. Barsotti, S. Giovannetti, R. Bianchi

    Pages 325-331

18. Kinetics of apolipoproteins A-I and A-II

    • L. Zech, E. J. Schaefer, J. C. Osborne Jr., R. L. Aamodt, H. B. Brewer Jr.

    Pages 333-355

19. The plasma apolipoproteins: Physiological properties and possible role in lipid disorders and atherogenesis

    • G. Baggio, E. Manzato, R. Fellin, G. Crepaldi

    Pages 357-372

20. Role of cell-surface receptors in the behaviour in vivo of transferren

    • E. Regoeczi

    Pages 373-395

This book represents a factual account of the proceedings of an international symposium on the pathophysiology of plasma protein metabolism, which was organised in October 1982 by the Plasmaprotein and Immunology Division of the C.N.R. Institute of Clinical Physiology at the University of Pisa (Italy). Several of the contributors are former members of the International Study Group on Plasma Protein Metabolism, the last meeting of which was held in Turin (Italy) in 1974, under the auspices of the scientific organisation of the same institute. The symposium took the form of a series of lectures, with the main objective of providing a positive contribution to the state of the art of several topics related to the kinetic and pathophysiological factors regulating the synthesis, distribution and degradation of plasma proteins. The first four chapters form a group, each one considering a special aspect of the kinetics of turnover and distribution of plasma proteins in general; particular attention is paid to the recent advances in the field of kinetic modelling, the choice of the best models and the optimisation of the experimental designs. The next seven chapters consider the regulation of synthesis, distribution and catab­ olism of various classes of plasma proteins including albumin, immunoglobulins, complement fractions and acute-phase proteins. The remaining chapters deal with metabolic studies of various plasma proteins (including tumour markers, coagUlation proteins and lipoproteins) in different disease states, such as malig­ nancies, coagulative disorders, malnutrition and the extensive group of athero­ sclerotic cardiovascular diseases.

• Lipid
• amino acid
• metabolism
• protein
• proteins
• receptor
• synthesis

• CNR Institute of Clinical Physiology, Fifth Medical Pathology of the University of Pisa, Pisa, Italy

  Giuliano Mariani

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