Abstract
Epstein-Barr virus (EBV) induced antigens can readily be detected in EBV-infected or transformed cells using a variety of immunological techniques. Monitoring of the immune responses to these different antigen has been instrumental in establishing an etiological association between EBV and different neoplastic diseases (Pearson, 1980).In addition, such antibodies have been shown to be of diagnostic and prognostic importance for certain histopathological types of nasopharyngeal carcinoma (NPC) and African Burkitt’s lymphoma. Thus these types of investigations over the past 20 years have served a useful purpose in studies on EBV and cancer. It is known, however, that most, if not all, of the EBV antigens are complexes composed of multiple determinants. Until recently little was known about the identity of the various proteins that composed these antigens or their functions. However, largely due to the development of monoclonal antibody technology, there has been good progress over the past few years in dissecting out the major components of the different EBV antigens complexes.
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© 1985 Martinus Nijhoff Publishing, Boston
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Pearson, G.R. (1985). Advances in the Identification of EBV-Specific Proteins: An Overview. In: Levine, P.H., Ablashi, D.V., Pearson, G.R., Kottaridis, S.D. (eds) Epstein-Barr Virus and Associated Diseases. Developments in Medical Virology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2625-0_38
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DOI: https://doi.org/10.1007/978-1-4613-2625-0_38
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