Epstein-Barr Virus and Associated Diseases

Proceedings of the First International Symposium on Epstein-Barr Virus-Associated Malignant Diseases (Loutraki, Greece—September 24–28, 1984)

  • Editors
  • P. H. Levine
  • D. V. Ablashi
  • G. R. Pearson
  • S. D. Kottaridis

Part of the Developments in Medical Virology book series (DIMV, volume 1)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Immunodeficiency Diseases

  3. EBV-Associated Malignancies

About this book

Introduction

It has been slightly more than two decades since the Epstein-Barr virus (EBV) was discovered by Prof. M.A. Epstein and his colleagues at the University of Bristol in their search for the causative agent of Burkitt's lymphoma. For several years EBV was a "virus in search of a disease." The first documentation that EBV was pathogenic for humans was in 1969 when Drs. Gertrude and Werner Henle identified it as the causative agent for infectious mononucleosis. Seroepidemiologic and biochemical studies subsequently linked EBV to Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC), and more recently to the X-linked lymphoproliferative syndrome. With its widespread pattern of infection and a predilection for producing clinical signs and symptoms in only certain individuals, EBV has provided a model for many other candidate oncogenic viruses, including papilloma viruses, herpes simplex, and HTLV/LAV. In 1975, an international workshop was sponsored by the National Cancer Institute to address the problem of EBV production, thus facilitating basic research on the virus. This proved to be the last international meeting on EBV for almost a decade. In the past, progress in both clinical and basic research on EBV has been presented in two types of international meetings, the international herpesvirus workshops devoted primarily to basic research on both human and animal herpesviruses, and the international symposia on NPC, in which EBV-related studies were interspersed with clinical, epidemiologic and other etiologic aspects of this important human neoplasm.

Keywords

antibody antigen cancer cell documentation immunodeficiency immunology immunosuppression infection infectious lymphoma molecular biology neoplasm research virus

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-2625-0
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9641-6
  • Online ISBN 978-1-4613-2625-0
  • About this book
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