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Brief Communication Detection of EBNA and Rescue of Transforming EBV in Megakaryocyte Cells Established in Culture

  • D. Morgan
  • D. V. Ablashi
Part of the Developments in Medical Virology book series (DIMV, volume 1)

Abstract

For the first time, cell lines of human megakaryocytes have been obtained from the circulating blood of normal donors and patients with various blood disorders (Morgan and Brodsky, 1984). The cultures consist predominantly of small “lymphoid” cells accompanied by giant multinucleated cells which spontaneously accumulate (Fig. 1, A and B). These giant cells have morphological properties common to well-defined megakaryocytes (Morgan and Brodsky, 1984). These “lymphoid” cells have no surface markers specific for lymphocytes, monocytes or granulocytes. Most significantly, greater than 80% of the cells do express antigens specific for and/or associated with megakaryocytes and platelets (Table 1).

Keywords

Polycythemia Vera Communication Detection Giant Multinucleated Cell Autoimmune Neutropenia Platelet Membrane Glycoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Glaser, R., The infection of epithelial cells with Epstein-Barr virus. In: U. Prasad, D.V. Ablashi, P.H. Levine and G.R. Pearson Teds.), Nasopharyngeal Carcinoma: Current Concepts. Univ. of Malaya, Kuala Lumpur, Malaysia, pp. 239–244 (1983).Google Scholar
  2. Kapff, C.T. and Jandl, J.H. (eds.) Blood: Atlas and Sourcebook of Hematology. Little, Brown & Co., Boston, pp. l2–13 (1981).Google Scholar
  3. Morgan, D.A. and Brodsky, I., Novel peripheral blood-derived human cell lines with properties of megakaryocytes. J. Cell Biol. 100: 565–573 (1984).CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • D. Morgan
    • 1
  • D. V. Ablashi
    • 2
  1. 1.Department of Haematology and OncologyHahnemann UniversityPhiladelphiaUSA
  2. 2.National Cancer InstituteBethesdaUSA

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