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The Hypertonic and Hypotonic Syndromes

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Physiology of Membrane Disorders

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Abstract

Extracellular fluid (ECF) osmotic homeostasis is regulated by a neurorenal axis involving thirst, antidiuretic hormone (ADH), and ADH-responsive renal epithelia (see Chapter 38). Osmoregulatory disorders can best be understood through consideration of two of the cardinal physiologic processes involved in osmotic homeostasis: the water repletion reaction and the cell volume regulatory response. The former provides a frame of reference for understanding the pathogenesis of these disorders, while the latter provides a means for considering the changes in brain volume which can attend osmoregulatory disorders.

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Author notes

  1. Steven C. Hebert

    Present address: Department of Internal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA

Authors and Affiliations

  1. Division of Nephrology, University of Texas Health Science Center, Houston, Texas, 77025, USA

    R. Michael Culpepper & Steven C. Hebert

  2. Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas, USA, 77025

    Thomas E. Andreoli

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  1. R. Michael Culpepper
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  3. Thomas E. Andreoli
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Editors and Affiliations

  1. University of Texas Health Science Center at Houston, Houston, Texas, USA

    Thomas E. Andreoli M.D.  & Stanley G. Schultz M.D.  & 

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph F. Hoffman Ph.D.

  3. University of California, San Diego La Jolla, California, USA

    Darrell D. Fanestil M.D.

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© 1986 Plenum Publishing Corporation

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Culpepper, R.M., Hebert, S.C., Andreoli, T.E. (1986). The Hypertonic and Hypotonic Syndromes. In: Andreoli, T.E., Hoffman, J.F., Fanestil, D.D., Schultz, S.G. (eds) Physiology of Membrane Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2097-5_52

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