Physiology of Membrane Disorders

1. Front Matter

   Pages i-xxvii

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2. The Nature of Biological Membranes

   1. Front Matter

      Pages 1-1

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   2. The Anatomy of Biological Interfaces

      • J. David Robertson

      Pages 3-24

   3. Composition and Dynamics of Lipids in Biomembranes

      • T. E. Thompson, C. Huang

      Pages 25-44

   4. Membrane Proteins

      • Guido Guidotti

      Pages 45-55

3. Methods for Studying Membranes

   1. Front Matter

      Pages 57-57

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   2. The Nature and Limitations of Electron Microscopic Methods in Biology

      • J. David Robertson

      Pages 59-82

   3. Isolation and Characterization of Biological Membranes

      • Rolf Kinne, George Sachs

      Pages 83-92

   4. Absorption and Optical Rotation Spectra of Biological Membranes

      • Marianna M. Long, Dan W. Urry

      Pages 93-109

   5. Mathematical Models of Membrane Transport Processes

      • Robert I. Macey

      Pages 111-131

   6. Application of Tracers to the Study of Membrane Transport Processes

      • John A. Jacquez

      Pages 133-150

   7. Principles of Electrical Methods for Studying Membrane Movements of Ions

      • Paul Horowicz, Martin F. Schneider, Ted Begenisich

      Pages 151-165

   8. The Study of Transport and Enzymatic Processes in Reconstituted Biological Systems

      • William P. Dubinsky

      Pages 167-173

4. General Problems in Membrane Biology

   1. Front Matter

      Pages 175-175

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   2. Principles of Water and Nonelectrolyte Transport across Membranes

      • James A. Schafer, Thomas E. Andreoli

      Pages 177-190

   3. Anion Transport in Erythrocytes

      • Philip A. Knauf

      Pages 191-220

   4. Active Transport of Na + and K + by Red Blood Cells

      • Joseph F. Hoffman

      Pages 221-234

   5. Weak Electrolyte Transport across Biological Membranes

      • Michael J. Jackson

      Pages 235-247

   6. Ion Permeation in Cell Membranes

      • Pamela A. Pappone, Michael D. Cahalan

      Pages 249-272

   7. Processing and Sorting of Proteins Synthesized in the Endoplasmic Reticulum

      • Michael J. Caplan, Steven A. Rosenzweig, James D. Jamieson

      Pages 273-281

The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition . Yet the purpose ofthe second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably. THE EDITORS xi Preface to the First Edition The purpose of this book is to provide the reader with a rational frame of reference for assessing the pa­ thophysiology of those disorders in which derangements of membrane transport processes are a major factor responsible for the clinical manifestations of disease. In the present context, we use the term "membrane transport to refer to those molecular processes whose cardinal function, broadly speaking, is processes" in a catholic sense, the vectorial transfer of molecules-either individually or as ensembles-across biological interfaces, the latter including those interfaces which separate different intracellular compartments, the cellular and extracellular com­ partments, and secreted fluids-such as glomerular filtrate-and extracellular fluids.

• ATPase
• Biomembran
• Organe
• Translation
• blood cell
• calcium channels
• electron microscopy
• erythrocyte
• metabolism
• microscopy
• pathophysiology
• physiology
• plasma membrane
• skeletal muscle
• tissue

• University of Texas Health Science Center at Houston, Houston, USA

  Thomas E. Andreoli, Stanley G. Schultz

• Yale University School of Medicine, New Haven, USA

  Joseph F. Hoffman

• University of California, San Diego La Jolla, USA

  Darrell D. Fanestil

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