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Active Transport in Escherichia Coli From Membrane to Molecule

  • Chapter
Physiology of Membrane Disorders

Abstract

Although the 1970s is regarded as the era of molecular genetics, when exciting breakthroughs made possible the isolation, cloning, and sequencing of genetic material from viruses to man, another revolution in our concepts of energy transduction in biological membranes also occurred over the same period of time, but without the same drama. Thus, in much the same way that the Crick-Watson double helix provided the backbone for many advances in molecular biology, the chemiosmotic hypothesis, formulated and refined by Peter Mitchell during the 1960s/1-5) is now the conceptual framework for a wide array of bioenergetic phenomena from photophosphorylation to the uptake and storage of neurogenic amines in the adrenal medulla. Curiously, however, the far-reaching importance of the chemiosmotic concept and the experimental evidence supporting its validity have gone relatively unnoticed because: (1) the chemiosmotic hypothesis was formulated initially to explain oxidative phosphorylation and is still strongly identified with this.

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  1. Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey, 07110, USA

    H. Ronald Kaback

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  1. University of Texas Health Science Center at Houston, Houston, Texas, USA

    Thomas E. Andreoli M.D.  & Stanley G. Schultz M.D.  & 

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph F. Hoffman Ph.D.

  3. University of California, San Diego La Jolla, California, USA

    Darrell D. Fanestil M.D.

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© 1986 Plenum Publishing Corporation

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Kaback, H.R. (1986). Active Transport in Escherichia Coli From Membrane to Molecule. In: Andreoli, T.E., Hoffman, J.F., Fanestil, D.D., Schultz, S.G. (eds) Physiology of Membrane Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2097-5_24

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  • DOI: https://doi.org/10.1007/978-1-4613-2097-5_24

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