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Antihypertensive Activity and Tolerability of Thiobutizide Alone or in Fixed Combination with Potassium Canrenoate in Essential Hypertension

  • P. Dessi’-Fulgheri
  • F. Bandiera
  • M. Oppes
  • P. Madeddu
  • F. Cocco
  • S. Rubattu
  • N. Glorioso
  • C. M. Troffa
  • A. Rappelli
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Diuretics have a number of well known adverse effects such as hyperglycaemia (or reduced carbohydrate tolerance), hyperlipidemia, hyperuricemia and hypokaliemia (1,2,3). The latter seems to mediate, at least in part, the negative effects on carbohydrate methabolism through a reduction of insulin release (4). The aim of our study has been to compare the antihypertensive and metabolic effects of a thiazide diuretic alone, thiobutizide, versus a combination of thiobutizide plus a potassium sparing agent, potassium canrenoate.

Keywords

Uric Acid Essential Hypertension Oral Glucose Tolerance Test Insulin Release Plasma Renin Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • P. Dessi’-Fulgheri
    • 1
  • F. Bandiera
    • 1
  • M. Oppes
    • 1
  • P. Madeddu
    • 1
  • F. Cocco
    • 1
  • S. Rubattu
    • 1
  • N. Glorioso
    • 1
  • C. M. Troffa
    • 1
  • A. Rappelli
    • 1
  1. 1.Cattedra di Patologia Medica IIUniversity of SassariSassariItaly

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