Antihypertensive Activity and Tolerability of Thiobutizide Alone or in Fixed Combination with Potassium Canrenoate in Essential Hypertension
Diuretics have a number of well known adverse effects such as hyperglycaemia (or reduced carbohydrate tolerance), hyperlipidemia, hyperuricemia and hypokaliemia (1,2,3). The latter seems to mediate, at least in part, the negative effects on carbohydrate methabolism through a reduction of insulin release (4). The aim of our study has been to compare the antihypertensive and metabolic effects of a thiazide diuretic alone, thiobutizide, versus a combination of thiobutizide plus a potassium sparing agent, potassium canrenoate.
KeywordsPlacebo Cholesterol Carbohydrate Angiotensin Renin
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