Antihypertensive Activity and Tolerability of Thiobutizide Alone or in Fixed Combination with Potassium Canrenoate in Essential Hypertension

  • P. Dessi’-Fulgheri
  • F. Bandiera
  • M. Oppes
  • P. Madeddu
  • F. Cocco
  • S. Rubattu
  • N. Glorioso
  • C. M. Troffa
  • A. Rappelli
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Diuretics have a number of well known adverse effects such as hyperglycaemia (or reduced carbohydrate tolerance), hyperlipidemia, hyperuricemia and hypokaliemia (1,2,3). The latter seems to mediate, at least in part, the negative effects on carbohydrate methabolism through a reduction of insulin release (4). The aim of our study has been to compare the antihypertensive and metabolic effects of a thiazide diuretic alone, thiobutizide, versus a combination of thiobutizide plus a potassium sparing agent, potassium canrenoate.

Keywords

Placebo Cholesterol Carbohydrate Angiotensin Renin 

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References

  1. 1.
    Kaplan, N.M. Am.J.Cardiol. 51: 621–627, 1983.PubMedCrossRefGoogle Scholar
  2. 2.
    Amery, A., Bulpitt, C., de Schaepdryver, A., Fagard, R., Hellemans, J., Mutsers, A., Berthaux, P., Deruytteere, M., Dollery, C., Forette, F., Lund-Johansen, P., Tuomileheto, J. Lancet I: 681–683, 1978.CrossRefGoogle Scholar
  3. 3.
    Murphy, M.B., Kohner, E., Lewis, P.J., Schumer, B., Dollery, C.T.: Lancet II 1293–1295, 1982.CrossRefGoogle Scholar
  4. 4.
    Conn, J.W. N.Engl.J.Med. 273: 1135–1138, 1965.PubMedCrossRefGoogle Scholar
  5. 5.
    Lindgarde, F., Malmquist, J., Balke, B. Acta Diabet.Lat. 20: 33–37, 1983.CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • P. Dessi’-Fulgheri
    • 1
  • F. Bandiera
    • 1
  • M. Oppes
    • 1
  • P. Madeddu
    • 1
  • F. Cocco
    • 1
  • S. Rubattu
    • 1
  • N. Glorioso
    • 1
  • C. M. Troffa
    • 1
  • A. Rappelli
    • 1
  1. 1.Cattedra di Patologia Medica IIUniversity of SassariSassariItaly

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