Abstract
Furosemide (F) is active from the luminal side of the thick ascending loop of Henle (1, 2). Changes in its renal clearance (Cr) should therefore influence the diuretic response. F has a Cr of around 100 ml/min and a somewhat lower nonrenal clearance (3). Binding of F to plasma albumin is very high (98 to 99%; ref.3), and the major part of its Cr is due to active tubular secretion by the organic acid transport system (2). This communication concerns changes in F pharmacokinetics, particularly factors behind reduced renal delivery of F as seen during dehydration.
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© 1987 Martinus Nijhoff Publishing, Boston
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Sjöström, P., Odlind, B., Beermann, B., Hammarlund-Udenaes, M. (1987). Changes in Furosemide Pharmacokinetics Induced by Dehydration. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_24
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DOI: https://doi.org/10.1007/978-1-4613-2067-8_24
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