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The ultrastructure of the cartilaginous tumors

  • Chapter
Ultrastructure of Skeletal Tissues

Abstract

Chondral tumors are the most frequent bone neo-plasms [1]. They are mainly classified as benign and malignant tumors or chondrosarcomas. Benign tumors are much more frequent than chondrosarcomas, which comprise about 7% of all bone tumors and 10–12.5% of malignant bone tumors [1,2], being the second most frequent malignant tumor. Most benign tumors are classified as chondromas and are subclassified, according to their location, as enchondromas (central), periosteal (juxtacortical), and osteochondromas (osteocartilaginous exostosis). The enchondromas and osteochondromas can be solitary or multiple. Besides the chondromas, two other benign tumor entities have been delineated, namely, the chondroblastoma and the chondromyxoid fibroma.

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References

  1. Schajowicz F: Tumors and tumor-like lesions of bone and joint. New York: Springer, 1981.

    Google Scholar 

  2. Dahlin DC: Bone tumors, 4th ed. Springfield, ILL: Thomas, 1988.

    Google Scholar 

  3. Aegerter E, Kirkpatrik JA Jr: Orthopedic Diseases: Physiology, Pathology, Radiology, 4th ed. Philadelphia: WB Saunders, 1975.

    Google Scholar 

  4. Schulz A: Ultrastrukturpathologie der Knochentumoren. Zelluläre Subklassifikation und Zytopathogenese. Stutt¬gart: Gustav Fischer, 1980.

    Google Scholar 

  5. Hirohata K, Morimoto K: Ultrastructure of bone and joint disease. Amsterdam: Excerpta Medica, 1971.

    Google Scholar 

  6. Winkelmann W, Becker W: Das Chondrom. Ein Beitrag zur feingeweblichen Morphologie. Zschr Orthop Grenz¬geb 114: 364 - 377, 1976.

    CAS  Google Scholar 

  7. Lichtenstein L, Hall JE: Periosteal chondroma. A dis¬tinctive benign cartilage tumor. J Bone Joint Surg [Am] 34: 691 - 697, 1952.

    Google Scholar 

  8. Jaffe HL: Juxtacortical chondroma. Bull Hosp Joint Dis 17: 20 - 29, 1956.

    PubMed  CAS  Google Scholar 

  9. Nosanchuk JK, Kaufer: Recurrent periosteal chon¬droma. Report of two cases and review of the literature. J Bone Joint Surg [Am] 51: 375 - 380, 1969.

    CAS  Google Scholar 

  10. Ewing J: Neoplastic diseases. Treatise on tumors, 3rd ed. Philadelphia: WB Saunders, 1928.

    Google Scholar 

  11. Codman EA: Epiphyseal chondromatous giant-cell tumors of the upper end of the humerus. Surg Gynecol Obstet 52: 543 - 548, 1931.

    Google Scholar 

  12. Jaffe HL, Lichtenstein L: Benign chondroblastoma of bone. A reinterpretation of the so called calcifying or chondromatous giant cell tumor. Am J Pathol 18: 969- 983, 1942.

    Google Scholar 

  13. Dahlin DC, Ivins JC: Benign chondroblastoma. A study of 125 cases. Cancer 30: 401 - 413, 1972.

    Article  PubMed  CAS  Google Scholar 

  14. Coleman SS: Benign chondroblastoma with recurrent soft-tissue and intra-articular lesions. J Bone Joint Surg [Am] 48: 1554 - 1560, 1966.

    CAS  Google Scholar 

  15. Schajowicz F, Gallardo H: Epiphyseal chondroblastoma of bone. A clinico-pathological study of sixty-nine cases. J Bone Joint Surg [Br] 52: 205 - 226, 1970.

    CAS  Google Scholar 

  16. Huvos AG, Higinbotham NL. Marcove RC, O’Leary P: Aggressive chondroblastoma. Review of the literature on aggressive behaviour and metastasis with a report of one new case. Clin Orthop 126: 266 - 272, 1977.

    PubMed  Google Scholar 

  17. Mirra JM, Ulich TR, Eckardt JJ, Bhuta S: “Aggressive” chondroblastoma. Light and ultramicroscopic findings after bloc resection. Clin Orthop 178: 276 - 284, 1983.

    PubMed  Google Scholar 

  18. Akai M, Tateishi A, Machinami R, Iwano K, Asao T: Chondroblastoma of the sacrum. A case report. Acta Orthop Scand 57: 378 - 381, 1986.

    Article  PubMed  CAS  Google Scholar 

  19. Cawlik Z, Witwick T: Chondroblastoma malignum pri- marium. Pat Pol 16: 181 - 189, 1965.

    Google Scholar 

  20. Kahn LB, Wood FM, Ackerman LV: Malignant chon-droblastoma. Report of two cases and review of the literature. Arch Pathol 45: 541 - 551.

    Google Scholar 

  21. Sirsat MV, Doctor VM: Benign chondroblastoma of bone. Report of a case of malignant transformation. J Bone Joint Surg [Br] 52: 741 - 745, 1970.

    CAS  Google Scholar 

  22. Wirman JA, Crisman JD, Aron BF, 1979. Metastatic chondroblastoma. Report of an unusual case treated with radiotherapy. Cancer 44: 87-93.

    Google Scholar 

  23. Riddell RD, Louis CJ, Bromberger H: Pulmonary me¬tastases from chondroblastoma of the tibia. Report of a case. J Bone Joint Surg [Br] 55: 848 - 853, 1973.

    CAS  Google Scholar 

  24. Green P, Whittaker RP: Benign chondroblastoma. Case report with pulmonary metastasis. J Bone Joint Surg [Am] 57: 418 - 420, 1975.

    CAS  Google Scholar 

  25. Denko JV, Krauel LH: Benign chondroblastoma of bone. An unusual localization in temporal bone. Arch Pathol 59: 710 - 711, 1955.

    CAS  Google Scholar 

  26. Sherman RS, Uzel AR: Benign chondroblastoma of bone. Its roentgen diagnosis. Am J Roentgenol, Radium Ther Nucl Med 76: 1132 - 1140, 1956.

    CAS  Google Scholar 

  27. Bruaczewski J, Lysakowska J, Rudowskiw: Chondro¬blastoma (Codman’s tumor) of the thoracic spine. J Bone Joint Surg [Br] 39: 705 - 710, 1957.

    Google Scholar 

  28. Wright JL, Sherman MS: An unusual chondroblastoma. J Bone Joint Surg [Am] 46: 597 - 600, 1964.

    Google Scholar 

  29. Wellmann KT: Chondroblastoma of the scapula. A case report with ultrastructural observations. Cancer 24: 408 - 416, 1969.

    Article  PubMed  CAS  Google Scholar 

  30. Carter D, Eggleston JC: Tumors of lower respiratory tract. In: Atlas of Tumor Pathology, Fasc 17, WH Hart- mann (ed), Washington DC: Armed Forces Institute of Pathology p 238, 1979.

    Google Scholar 

  31. Weinrauch L, Katz M, Pizon G: Primary benign chon-droblastoma cutis: Extraskeletal manifestation without bone involvement. Arch Dermatol 123: 24 - 26, 1987.

    Article  PubMed  CAS  Google Scholar 

  32. Welsh RA, Meyer AT: A histogenetic study of chondro¬blastoma. Cancer 17: 578 - 585, 1964.

    Article  PubMed  CAS  Google Scholar 

  33. Levine G, Bensch K: Chondroblastoma, the nature of the basic cell. A study by means of histochemistry, tis¬sue culture electron microscopy and autoradiography. Cancer 29: 1456 - 1562, 1972.

    Article  Google Scholar 

  34. Steiner GC: Ultrastructure of benign cartilaginous tumors of intraosseous origin. Hum Path 10: 71 - 86, 1979.

    Article  PubMed  CAS  Google Scholar 

  35. De Santis E: Ultrastructural aspects of chondroblastoma of the skeleton. Arch Putti Chir Orgam Mov 30: 79 - 88, 1980.

    CAS  Google Scholar 

  36. Ushigome S, Takakukawa T, Shinagawa T, Takagi M, Kishimoto H, Mori N: Ultrastructure of cartilaginous tumors and S-100 protein in the tumors. With reference to the histogenesis of chondroblastoma, chondromyxoid fibroma and mesenchymal chondrosarcoma. Acta Pathol Jpn 34: 1285 - 1300, 1984.

    PubMed  CAS  Google Scholar 

  37. Weiss C, Rosenberg LC, Helfet AJ: An ultrastructural study of normal young adult human articular cartilage. J Bone Joint Surg 50A: 663 - 674, 1968.

    PubMed  CAS  Google Scholar 

  38. Tornberg DN, Rice RW, Johnston AD: The ultrastruc- ture of chondromyxoid-fibroma. Clin Orthop 95: 295- 299, 1973.

    Google Scholar 

  39. Mazanac K: Presence de la “zonule nucleum limitans” dans quelques cellules humaines. J Microscopic 6: 1027— 1032, 1967.

    Google Scholar 

  40. Martinez-Tello FJ, Navas-Palacios JJ: The ultrastruc- ture of conventional, parosteal and periosteal osteo¬sarcomas. Cancer 50: 949 - 961, 1982.

    Article  PubMed  CAS  Google Scholar 

  41. Ghadially FN, Dick CE, Lalonde JMA: Thickening of the nuclear fibrous lamina in injured human semilunar cartilages. J Anat 131: 717 - 722, 1980.

    PubMed  CAS  Google Scholar 

  42. Jaffe HL, Lichtenstein L: Chondromyxoid fibroma of bone: A distinctive benign tumor likely to be mistaken especially for chondrosarcoma. Arch Pathol 45: 541- 551, 1948.

    Google Scholar 

  43. Ottolenghi CE, Petracchi LJ: Chondromyxosarcoma of the calcaneus. J Bone Joint Surg [Am] 35: 211 - 214, 1953.

    Google Scholar 

  44. Dahlin DC: Chondromyxoid fibroma of bone with em¬phasis on its morphological relationship to benign chon¬droblastoma. Cancer 9: 195 - 203, 1956.

    Article  PubMed  CAS  Google Scholar 

  45. Taniguchi S: Electron microscopic study of chondro¬sarcoma. Chiba Med J 43: 768 - 788, 1976.

    Google Scholar 

  46. Spjut HJ, Dorfman HD, Ackerman LV: Tumors of bone and cartilage. In: Atlas of Tumor Pathology, Fasc 5, 2nd ser. HI Firminger (ed), Washington DC: Armed Forces Institute of Pathology, p 104 - 107, 1971.

    Google Scholar 

  47. Schajowicz F, Cabrini RJ, Simes DDS, Klein-Szanto AJP: Ultrastructure of chondrosarcoma. Clin Orthop 100: 3/8-386, 1974.

    Google Scholar 

  48. Erlandson RA, Huvos AG: Chondrosarcoma, a light and electron microscopic study. Cancer 34: 1642 - 1652, 1974.

    Article  PubMed  CAS  Google Scholar 

  49. Remagen W, Gudat F, Heitz P: Histochemical and electron microscopic aspects of bone tumor diagnosis. Recent Results Cancer Res 54: 157 - 165, 1976.

    PubMed  Google Scholar 

  50. Martinez-Tello FJ, Navas-Palacios JJ: Ultrastructural study of conventional chondrosarcomas and myxoid- and mesenchymal-chondrosarcomas. Virchows Arch [A] 396: 197 - 211, 1982.

    Article  CAS  Google Scholar 

  51. Dahlin DC, Beabout JW: Dedifferentiation of low grade chondrosarcomas. Cancer 28: 461 - 466, 1971.

    Article  PubMed  CAS  Google Scholar 

  52. Mirra JM, Marcove RC: Fibrosarcomatous dedifferen¬tiation of primary and secondary chondrosarcoma. Re¬view of five cases. J Bone Joint Surg [Amj 56: 285 - 296, 1974.

    CAS  Google Scholar 

  53. Kahn LB: Chondrosarcoma with dedifferentiated foci. A comparative and ultrastructural study. Cancer 37: 1365 - 1375, 1976.

    Article  PubMed  CAS  Google Scholar 

  54. Lichtenstein L, Berstein D: Unusual benign and malig¬nant chondroid tumors of bone. A survey of some mesenchymal cartilage tumors and malignant chondro- blastic tumors, including a few multicentric ones, as well as many atypical benign chondroblastomas and chondro¬myxoid fibromas. Cancer 12: 1142 - 1157, 1959.

    Article  Google Scholar 

  55. Salvador AH, Beabout JW, Dahlin DC: Mesenchymal chondrosarcoma observations on 30 new cases. Cancer 28: 605 - 615, 1971.

    Article  PubMed  CAS  Google Scholar 

  56. Guccion JG, Font RL, Enzinger FM, Zimmerman LE: Extraskeletal mesenchymal chondrosarcoma. Arch Pathol 95: 336 - 340, 1973.

    PubMed  CAS  Google Scholar 

  57. Raskind R, Grant S: Primary mesenchymal chondro¬sarcoma of the cerebrum: Report of a case. J Neurosurg 24: 676 - 678, 1966.

    Article  PubMed  CAS  Google Scholar 

  58. Rollo JL, Green WR, Kahn LB: Primary meningeal mesenchymal chondrosarcoma. Arch Pathol Lab Med 103: 239 - 243, 1979.

    PubMed  CAS  Google Scholar 

  59. Scheitenhauer BW, Rubinstein LJ: Meningeal chondro¬sarcoma: Report of 8 cases with review of the literature. Cancer 42: 2744 - 2752, 1978.

    Article  Google Scholar 

  60. Wu WO, Lapi A: Primary nonskeletal intracranial cartilaginous neoplasms: Report of a chondroma and a mesenchymal chondrosarcoma. J Neurol Neurosurg Psychiatry 33: 469 - 475, 1970.

    Article  PubMed  CAS  Google Scholar 

  61. Zucker DK, Horoupian DS: Dural mesenchymal chon¬drosarcoma: Case report. J Neurosurg 48: 829 - 833, 1978.

    Article  PubMed  CAS  Google Scholar 

  62. Reeh MJ: Hemangiopericytoma with cartilaginous dif¬ferentiation involving orbit. Arch Ophthalmol 75: 82- 83, 1966.

    Google Scholar 

  63. Muir CS, Seah CS: Primary chondrosarcoma of the mitral valve. Thorax 21: 254 - 262, 1966.

    Article  PubMed  CAS  Google Scholar 

  64. Harwood AR, Krajbich JI, Fornasien VL: Mesenchy¬mal chondrosarcoma: A report of 17 cases. Clin Orthop 158: 144 - 148, 1981.

    PubMed  Google Scholar 

  65. Huvos AG, Rosen G, Dabska M, Marcove RC: Mesen¬chymal chondrosarcoma. A clinicopathologic analysis of 35 patients. Cancer 51: 1230 - 1237, 1983.

    Article  PubMed  CAS  Google Scholar 

  66. Nakashima Y, Unni KK, Shives TC, Swee RG, Dahlin DC: Mesenchymal chondrosarcoma of bone and soft tissue: A review of 111 cases. Cancer 57: 2444 - 2453, 1986.

    Article  PubMed  CAS  Google Scholar 

  67. Steiner GC, Mirra JM, Bullough PG: Mesenchymal chondrosarcoma. A study of the ultrastructure. Cancer 32: 926 - 939, 1973.

    Article  PubMed  CAS  Google Scholar 

  68. Mandalenakis N: Chondrosarcome mesenchymateux. Etude histologique et ultrastructurale. Ann Anat Pathol 19: 176 - 186, 1974.

    Google Scholar 

  69. Mikata A, Iri H, Inuyama Y: Mesenchymal chondro¬sarcoma. A case report with an ultrastructural study and review of Japanese literatures. Acta Pathol Jpn 27: 93 - 109, 1977.

    PubMed  CAS  Google Scholar 

  70. Fu YS, Kay S: A comparative ultrastructural study of mesenchymal chondrosarcoma and myxoid chondro¬sarcoma. Cancer 33: 1531 - 1542, 1974.

    Article  PubMed  CAS  Google Scholar 

  71. Dabska M, Huvos AG: Mesenchymal chondrosarcoma in the young. A clinicopathologic study of 19 patients with explanation of histogenesis. Virchows Arch [A] 399: 89 - 104, 1983.

    CAS  Google Scholar 

  72. Hutter RVP, Foote FW, Francis KC, Sherman RS: Primitive multipotential primary sarcoma of bone. Can¬cer 19: 1 - 25, 1966.

    Article  CAS  Google Scholar 

  73. Jacobson SA: Polyhistioma. A malignant tumor of bone and extraskeletal tissues. Cancer 40: 2116 - 2130, 1977.

    Article  PubMed  CAS  Google Scholar 

  74. Unni KK, Dahlin DC, Beabout JW, Sim FM: Chondro¬sarcoma: Clear cell variant. J Bone Joint Surg 58A: 676 - 683, 1976.

    PubMed  CAS  Google Scholar 

  75. Forest M, Dahdoum B, Abelanet R: Une nouvelle varíete de chondrosarcome: Les sarcomes dits “chon- droblastiques ou chondrosarcomes a cellules claires.” Etude anatomoclinique et ultrastructurale de 5 obser¬vations. Arch Anat Cytol Pathol (Paris) 26: 5 - 11, 1978.

    CAS  Google Scholar 

  76. Le Charpentier Y, Forest W, Postel M, Tomeno B, Abelanet R: Clear cell chondrosarcoma. A report of five cases including ultrastructural study. Cancer 44: 622 - 629, 1979.

    Article  CAS  Google Scholar 

  77. Faraggiana T, Sender B, Glucksman P: Light- and electron-microscopic study of clear cell chondrosarcoma. Am J Clin Pathol 75: 117 - 121, 1981.

    PubMed  CAS  Google Scholar 

  78. Dupare J, Badelon O, Bocquect L, Grossin M, Feld- mann G: Un cas inhabitual de chondrosarcome a cellule claires avec des locations tumorales intra-synoviales. Rev Chir Orthop 71: 127 - 131, 1985.

    Google Scholar 

  79. Ohno I, Park P, Oguro K, Takeda H, Omata M, Taka- yama H, Fujinuma A, Abe M: Ultrastructural study of a clear cell chondrosarcoma, Ultrastruct Pathol 10: 321 - 330, 1986.

    Article  PubMed  CAS  Google Scholar 

  80. Stewart FW: Case 211, a division of laboratories and research. Albany, New York, 1948.

    Google Scholar 

  81. Stout AP, Verner EW: Chondrosarcoma of the extra- skeletal soft tissues. Cancer 6: 581 - 590, 1953.

    Article  PubMed  CAS  Google Scholar 

  82. Enzinger FM, Shiraki M: Extraskeletal myxoid chon¬drosarcoma. An analysis of 34 cases. Hum Pathol 3: 421 - 435, 1972.

    Article  PubMed  CAS  Google Scholar 

  83. Pardo-Mindán FJ, Cañadell JM, Herranz P, Imizoc JL, Vazquez JJ: Sarcoma cordoide del femur. Estudio al microscopio óptico y electrónico de un caso. Rev Med Univ Navarra 19: 133 - 141, 1975.

    PubMed  Google Scholar 

  84. Steiner G: Myxoid chondrosarcoma of the os calcis: A case report. Foot Ankle 5: 84 - 91, 1984.

    PubMed  CAS  Google Scholar 

  85. Mehio AR, Ferenczy A: Extraskeletal myxoid chondro¬sarcoma with “chordoid” features (chordoid sarcome). Am J Clin Pathol 70: 700 - 705, 1978.

    PubMed  CAS  Google Scholar 

  86. Fukuda T: Extraskeletal myxoid chondrosarcoma arising from retroperitoneum J Clin Pathol 85: 514 - 519, 1986.

    CAS  Google Scholar 

  87. Smith MT, Farinacci CJ, Carpenter HA, Bannayan GA: Extraskeletal myxoid chondrosarcoma. A clinicopatho- logical study. Cancer 37: 821 - 827, 1976.

    Article  PubMed  CAS  Google Scholar 

  88. Kindblom LG, Angervall L: Myxoid chondrosarcoma of the synovial tissue. A clinicopathologic, histochemical and ultrastructural analysis. Cancer 52: 1886 - 1895, 1983.

    Article  PubMed  CAS  Google Scholar 

  89. Laskowsky I: Parachordoma (abstract). International Cancer Congress. 8: 262.

    Google Scholar 

  90. Dardick I, Lagacé R, Carlier MT, Yung RC: Chordoid sarcoma (extraskeletal myxoid chondrosarcoma). A light and electron microscope study. Virchows Arch [A] 399: 61 - 78, 1983.

    CAS  Google Scholar 

  91. Weiss SW: Ultrastructure of the so called “chordoid sarcoma.” Evidence supporting cartilagineous differen¬tiation. Cancer 37: 300 - 306, 1976.

    Article  PubMed  CAS  Google Scholar 

  92. Vernick S, Kay S, Escobar M, Sperber E, Rosato F: Intracisternal tubules in a myxoid chondrosarcoma. Arch Pathol Lab Med 101: 556 - 566, 1977.

    PubMed  CAS  Google Scholar 

  93. De Blois G, Wang S, Kay S: Microtubular aggregates within rough endoplasmic reticulum: An unusual ultra- structural feature of extraskeletal myxoid chondrosar¬coma. Hum Path 17: 469 - 475, 1986.

    Article  PubMed  CAS  Google Scholar 

  94. Mackay B, Ayala AG: Intracisternal tubules in human melanoma cells. Ultrastruct Path 1: 1 - 6, 1980.

    Article  CAS  Google Scholar 

  95. Valderrama E, Lipper S, Kalm LB, Marc J: Chondroid chordoma. Electron-microscopic study of two cases. Am J Surg Pathol 7: 625 - 632, 1983.

    Article  PubMed  CAS  Google Scholar 

  96. Jaworsky RC: Intramitochondrial paracrystalline inclu¬sion in chondrosarcoma. Pathology 16: 172 - 173, 1984.

    Article  Google Scholar 

  97. Ghadially FN: Ultrastructural Pathology of the Cell and Matrix, 2nd ed. London: Butterworths. p 406-407, 1982.

    Google Scholar 

  98. Pardo-Mindán FJ, Guillen FJ, Villas C, Vazquez JJ: A comparative ultrastructural study of chondrosarcoma, chordoid sarcoma and chordoma. Cancer 47: 2661- 2669, 1981.

    Google Scholar 

  99. Povysil C, Matejowsky Z: A comparative ultrastructural study of chondrosarcoma, chordoid sarcoma, chordoma and chordoma periphericum. Pathol Res Pract 179: 546 - 559, 1985.

    PubMed  CAS  Google Scholar 

  100. Robertson DI, Hogg GR: Chordoid sarcoma: Ultra- structural evidence supporting a synovial origin. Cancer 45: 520 - 527, 1980.

    Article  PubMed  CAS  Google Scholar 

  101. Bender BL, Barnes L, Yunis EI: Intraosseous “chor¬doid” sarcoma, chondroblastic or lipoblastic origin. Virchows Arch [A] 387: 241 - 249, 1980.

    Article  CAS  Google Scholar 

  102. Godman GC, Porter KR: Chondrogenesis studied with the electron microscope. J Biophys Biochem Cytol 8: 719 - 760, 1960.

    Article  PubMed  CAS  Google Scholar 

  103. Anderson HC: Electron microscopic study of induced cartilage development and calcification. J Cell Biol 35: 81 - 191, 1967.

    Article  PubMed  CAS  Google Scholar 

  104. Silverberg R: Ultrastructure of articular cartilage in health and disease. Clin Orthop 57: 233 - 257, 1968.

    Google Scholar 

  105. Vilanova JR, Simon-Marin R, Burgos-Bretones J, Ramirez MM, Rivera-Pomar JM: Nonconventional chondrosarcoma and chondrogenesis. Histopathology 9: 719 - 728, 1985.

    Article  PubMed  CAS  Google Scholar 

  106. Roth J: The colloidal gold marker system for light and electron microscopic cytochemistry. Theory and ap¬plication. In: Techniques in Immunocytochemistry, Vol. 2. GR Bullock, P Petrusz (eds), London: Academic Press, p 217 - 284, 1983.

    Google Scholar 

  107. Roth J: Light- and electron-microscopic localization of antigens with the protein A-gold (pAg) technique. In: Advances in Immunohistochemistry. A DeLellis (ed). Masson Monographs in Diagnostic Pathology, no. 7. New York: Masson Publishing, p 43–65, 1984.

    Google Scholar 

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Martinez-Tello, F.J., Martinez-Gonzalez, M.A. (1990). The ultrastructure of the cartilaginous tumors. In: Bonucci, E., Motta, P.M. (eds) Ultrastructure of Skeletal Tissues. Electron Microscopy in Biology and Medicine, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1487-5_10

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