Ultrastructure of Skeletal Tissues

1. Front Matter

   Pages i-xi

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2. The ultrastructure of calcified tissues: Methods and technical problems

   • A. Larry Arsenault

   Pages 1-18

3. The original contributions of the scanning electron microscope to the knowledge of bone structure

   • Gastone Marotti

   Pages 19-39

4. Collagen mineralization: Aspects of the structural relationship between collagen and the apatitic crystallites

   • H. J. Höhling, Rudolf H. Barckhaus, Ernst-R. Krefting, Jörg Althoff, Peter Quint

   Pages 41-62

5. Ultrastructural immunohistochemistry of noncollagenous proteins in calcified tissues

   • Paolo Bianco

   Pages 63-78

6. Ultrastructure of cartilage

   • Ernst B. Hunziker, Wolfgang Herrmann

   Pages 79-109

7. Ultrastructural cytochemistry of cartilage proteoglycans and their relation to the calcification process

   • Minoru Takagi

   Pages 111-127

8. Ultrastructural localization of calcium in normal and pathologic cartilage

   • Dina Lewinson, Michael Silbermann

   Pages 129-152

9. Glucocorticoid effects on the ultrastructure of epiphyseal cartilage

   • Lyle C. Dearden

   Pages 153-171

10. Ultrastructural aspects of osteochondrodysplasias

    • Ernesto Ippolito, Jerry A. Maynard, Angiola Pedrini-Mille, Vittorio Pedrini

    Pages 173-188

11. The ultrastructure of the cartilaginous tumors

    • Francisco J. Martinez-Tello, Miguel A. Martinez-Gonzalez

    Pages 189-207

12. The electron microscopic structure of the osteoblast

    • Johannes P. Scherft, Cornelis G. Groot

    Pages 209-222

13. The ultrastructure of the osteocyte

    • Ermanno Bonucci

    Pages 223-237

14. Ultrastructural biology and pathology of the osteoclast

    • Sandy C. Marks Jr, Steven N. Popoff

    Pages 239-252

15. The ultrastructural effects of parathyroid-hormone, calcitonin, and vitamin D on bone

    • Steven E. Weisbrode, Charles C. Capen

    Pages 253-269

16. The ultrastructure of bone tumors

    • German C. Steiner

    Pages 271-291

17. Back Matter

    Pages 293-299

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The calcified tissues have fundamental functions in the biology of organisms, not only because their strength, solidity, and elasticity permit movement and mechanical activities, and protect soft tissues against traumatic forces, but also on account of their role in mineral homeostasis. For this reason, extensive investigation in the last 30 years has provided much to explain the complex chemical and physical processes occurring in cells and matrices composing the skeleton, and their alterations in pathological conditions. The use of ultrastructural methods such as immunocytochemistry, scanning and transmission electron microscopy, cytoautoradiography, freeze/fracture etching, high voltage, etc. has proven to be of great value when applied to cells and matrix components of bone and cartilage, in spite of the technical difficulties due to the hardness of these tissues. However, available information on this subject is disseminated in a variety of scientific and medical articles. This volume is an attempt to collect together the most significant data on the ultrastructure of cartilage and bone in normalcy and pathology. Obviously, it cannot be a complete report of all these data, its principal aim being that of: a) giving a comprehensive statement of the results concerning the basic structures common to these tissues, especially collagen fibrils, noncollagenous proteins, and proteoglycans, and their relationships with the mineral substance (for which another volume of this series can also be consulted; see Ruggeri A. , Motta P. M. (eds.

• bone
• cartilage
• fracture
• pathology
• skeleton
• tissue
• trauma

• Department of Human Biopathology, Faculty of Medicine, University “La Sapienza” of Rome, Italy

  E. Bonucci

• Department of Anatomy, Faculty of Medicine, University “La Sapienza” of Rome, Italy

  P. M. Motta

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