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Progesterone/Estradiol Ratios Predict Outcome in In Vitro Fertilization

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Advances in Assisted Reproductive Technologies

Abstract

Despite increasing experience with in vitro fertilization (IVF), there are few endocrinological markers which can serve as a prospective predictor of IVF success. An initial investigation utilized periovulatory estradiol (E2) levels after administration of low dose human menopausal gonadotropin followed by a coasting period before giving human chorionic gonadotropin (hCG). The levels of estradiol studied were lower than those typically seen in many IVF programs today.1 Others have studied post-transfer progesterone/E2 ratios and suggested a predictive value.2 This report summarizes our efforts to further elucidate endocrinological markers that can be used to predict success or potential success in IVF.

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References

  1. H.W. Jones, A. Acosta, M.C. Andrews, et al., The importance of the follicular phase to success and failure in in vitro fertilization. Fertil. Steril. 40:31, 1983.

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  2. A.A. Leidley-Baird, C. ONeill, M.J. Sinosich, et al., Failure of implantation in human invitro fertilization and embryo patients: The effects of altered progesterone/estrogen ratios in humans and mice. Fertil Steril. 45:69, 1986.

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  3. N. Laufer, A.H. Decherney, B.C. Tarlatzkis, F. Naftolin, The association between preovulatory serum 17 b estradiol pattern and conception in human menopausal gonadotropin-human chorionic gonadotropin stimulation, Fertil. Steril. 46:73, 1986.

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  5. C.J. Richards-Kustan, G.J. Garrisi, H. Wiczyk, et al., P/E ratios predict outcome in in vitro fertilization, Submitted for Publication, June, 1989.

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Shlomo Mashiach M.D. Zion Ben-Rafael M.D. Neri Laufer M.D. Joseph G. Schenker M.D.

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© 1990 Plenum Press, New York

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Richards-Kustan, C.J. et al. (1990). Progesterone/Estradiol Ratios Predict Outcome in In Vitro Fertilization. In: Mashiach, S., Ben-Rafael, Z., Laufer, N., Schenker, J.G. (eds) Advances in Assisted Reproductive Technologies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0645-0_41

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  • DOI: https://doi.org/10.1007/978-1-4613-0645-0_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7907-5

  • Online ISBN: 978-1-4613-0645-0

  • eBook Packages: Springer Book Archive

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