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Cellular Localization of Erythropoietin Gene Transcription

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Molecular Biology of Erythropoiesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 271))

Abstract

Erythropoietin producing cells were identified in the murine hypoxic kidney by in situ hybridization. The positive cells were peritubular cells, most likely endothelial cells of the cortex and outer medulla. Glomerular and tubular cells were not labelled.

In three patients with renal adenocarcinomas associated with polycythemia, a strong Epo message was observed on Northern blot analysis. Using in situ hybridization, a strong labelling was observed in all cases on the tumor cells which are of tubular origin.

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Author information

Authors and Affiliations

  1. INSERM U152, Hopital Cochin, Paris, France

    Catherine Lacombe, Nicole Casadevall, Bruno Varet & Pierre Tambourin

  2. INSERM U28, Hopital Broussais, Paris, France

    Jean-Louis Da Silva, Patrick Bruneval, Jean-Loup Salzmann, Jean-Pierre Camilleri & Jean Bariety

Authors
  1. Catherine Lacombe
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  2. Jean-Louis Da Silva
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  3. Patrick Bruneval
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  4. Jean-Loup Salzmann
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  5. Nicole Casadevall
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  6. Jean-Pierre Camilleri
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  7. Jean Bariety
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  8. Bruno Varet
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  9. Pierre Tambourin
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Editor information

Editors and Affiliations

  1. University of Connecticut Health Center, Farmington, Connecticut, USA

    Joao L. Ascensao

  2. Veterans Administration Medical Center, Reno, Nevada, USA

    Esmail D. Zanjani

  3. Veterans Administration Hospital, Jackson, Mississippi, USA

    Mehdi Tavassoli

  4. National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

    Alan S. Levine

  5. University of Nevada, Reno, Nevada, USA

    F. Roy MacKintosh

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© 1989 Plenum Press, New York

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Lacombe, C. et al. (1989). Cellular Localization of Erythropoietin Gene Transcription. In: Ascensao, J.L., Zanjani, E.D., Tavassoli, M., Levine, A.S., MacKintosh, F.R. (eds) Molecular Biology of Erythropoiesis. Advances in Experimental Medicine and Biology, vol 271. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0623-8_8

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  • DOI: https://doi.org/10.1007/978-1-4613-0623-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7897-9

  • Online ISBN: 978-1-4613-0623-8

  • eBook Packages: Springer Book Archive

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