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Metabolism of Recombinant Human Erythropoietin in the Rat

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Molecular Biology of Erythropoiesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 271))

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Abstract

Erythropoietin is the only hematopoietic growth factor which behaves like a hormone. Produced primarily in the kidneys and to a small extent in the liver, erythropoietin interacts with primitive erythroid progenitor cells in the bone marrow. Under normal circumstances, the plasma concentracentration of erythropoietin is maintained within narrow limits but is subject to change according to the adequacy of tissue oxygenation. Thus, tissue hypoxia stimulates erythropoietin production while a surfeit of oxygen suppresses it. Erythropoietin, however, is never absent from the plasma since it is an obligatory growth factor for erythroid progenitor cells1.

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Author information

Authors and Affiliations

  1. Division of Hematology Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Jerry L. Spivak

Authors
  1. Jerry L. Spivak
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Editor information

Editors and Affiliations

  1. University of Connecticut Health Center, Farmington, Connecticut, USA

    Joao L. Ascensao

  2. Veterans Administration Medical Center, Reno, Nevada, USA

    Esmail D. Zanjani

  3. Veterans Administration Hospital, Jackson, Mississippi, USA

    Mehdi Tavassoli

  4. National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

    Alan S. Levine

  5. University of Nevada, Reno, Nevada, USA

    F. Roy MacKintosh

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© 1989 Plenum Press, New York

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Spivak, J.L. (1989). Metabolism of Recombinant Human Erythropoietin in the Rat. In: Ascensao, J.L., Zanjani, E.D., Tavassoli, M., Levine, A.S., MacKintosh, F.R. (eds) Molecular Biology of Erythropoiesis. Advances in Experimental Medicine and Biology, vol 271. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0623-8_5

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  • DOI: https://doi.org/10.1007/978-1-4613-0623-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7897-9

  • Online ISBN: 978-1-4613-0623-8

  • eBook Packages: Springer Book Archive

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