Abstract
The single most important tool for the development of high specific activity or no-carrier-added (nca) radiopharmaceuticals is a radio-HPLC. The reason for making such a strong statement in favor of HPLC rather than other chromatographic methods is that HPLC offers many advantages over other chromatographic methods. For example, the columns employed in HPLC are much more efficient than conventional thin-layer chromatography (TLC) plates, and the isolation of the products is simpler, more convenient, and safer than either TLC or gas chromatography.
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Abstract
Eckelman, W.C., ed.: Receptor-Binding Radiotracers. Vols. 1, 2, CRC Press, Boca Raton, 1982.
Wong, S. H.-Y.: Roles of high-performance liquid chromatography in nuclear medicine. In Advances in Chromatography. Vol. 19, Marcel Dekker, New York, 1981.
Berger, G., Maziere, M., Godot, J.J., Prenant, C. and Comar, D. Purification of 11C labeled radiopharmaceuticals by LC. In BiologicalIBiomedical Applications of Liquid Chromatography IV. Chromatographic Science Series, Vol. 20, Hawk, G.L. ed., Marcel Dekker, New York, 1982, pp. 223–230.
Berger, G. and Knipper, R.: Remotely controlled injection of a highly radioactive solution into a liquid chromatograph. J. Radioanalytic Chem. 56: 251–252, 1980.
Roberts, J.R.: Development of continuous flow monitoring in column chromatography. In Radiochromatography. Journal of Chromatography Library, Vol. 14, Elsevier, New York, 1978.
von Stetten, 0. and Schlett, R.: Purification of 125I-labeled compounds by high- performance liquid chromatography with on-line detection. J. Chromatogr. 254: 229 - 235, 1983.
Grant, P.M., Whipple, R.E., Barnes, J.W., Bentley, G.E., Wanek, P.M. and O’Brien, H.A.: The production and recovery of Br-77 at Los Alamos for nu-clear medicine studies. J. Inorg. Nucl. Chem. 43: 2217–2222, 1981.
Wilbur, D.S., Garcia, S.R., Adam, M.J. and Ruth, T.J.: An evaluation of the introduction of bromine into high specific activity radiobrominations. J. La-belled Compd. Radiopharm. 21: 767–779, 1984.
Roberts, J.R.: Radio-thin-layer chromatography. In Radiochromatography. Journal of Chromatography Library, Vol. 14, Elsevier, New York, 1978.
Wilbur, D.S., Anderson, K.W., Stone, W.E. and O’Brien, H.A.: Radiohalogenation of non activated aromatic compounds via aryltrimethylsilyl intermediates. J. Labelled Compd. Radiopharm. 19: 1171–1188, 1982.
Wilbur, D.S., Stone, W.E. and Anderson, K.W.: Regiospecific incorporation of bromine and iodine into phenols using (trimethylsilyl)phenol derivatives. J. Org. Chem. 48: 1542–1544, 1983.
Wilbur, D.S. and Svitra, Z.V.: Electrophilic radiobrominations of hippuric acid: an example of the utility of aryltrimethylsilane intermediates. J. Labelled Compd. Radiopharm. 21: 415–428, 1984.
Wilbur, D.S., Svitra, Z.V. and O’Brien, H.A.: Applications of aryltrimethylsi- lanes in radiobrominations. J. Nucl. Med. 24:P43, Abstract, 1983.
Wilbur, D.S.: Synthesis and radiobrominations of some trimethylsilylphenethylamines. J. Nucl. Med. 25:P124, Abstract, 1984.
Takeuchi, T. and Ishii, D.: Ultra-micro high-performance liquid chromatography. J. Chromatogr. 190: 150–155, 1980.
Fjeldstred, J.C. and Lee, M.L.: Capillary supercritical fluid chromatography. Anal. Chem. 56: 619A–628A, 1984.
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Wilbur, D.S. (1986). Development of No-Carrier-Added Radiopharmaceuticals with the Aid of Radio-HPLC. In: Wieland, D.M., Tobes, M.C., Manger, T.J. (eds) Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4854-5_11
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DOI: https://doi.org/10.1007/978-1-4612-4854-5_11
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