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Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry

  • Book
  • © 1986

Overview

Editors:
  1. Donald M. Wieland

    1. Division of Nuclear Medicine Department of Internal Medicine, The University of Michigan, Ann Arbor, USA

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  2. Michael C. Tobes

    1. Division of Nuclear Medicine Department of Internal Medicine, The University of Michigan, Ann Arbor, USA

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  3. Thomas J. Manger

    1. Division of Nuclear Medicine Department of Internal Medicine, The University of Michigan, Ann Arbor, USA

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Thin-Layer Chromatography

    1. Front Matter

      Pages 1-1
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    2. Instrumental Evaluation of Thin-Layer Chromatograms

      • Colin F. Poole, Hal T. Butler, Myra E. Coddens, Sheila A. Schuette
      Pages 3-37

    3. Radioanalytical Techniques: ITLC, TLC, Mini-Columns, and Electrophoresis

      • Alan P. Carpenter Jr.
      Pages 39-70

    4. Radio-Thin-Layer Chromatogram Imaging Systems—Performance and Design

      • Sheryl J. Hays
      Pages 71-77

    5. Detection of Radiochromatograms and Electropherograms with Position-Sensitive Wire Chambers

      • Heinz Filthuth
      Pages 79-99

  3. High Pressure Liquid Chromatography

    1. Front Matter

      Pages 101-101
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    2. Components for the Design of a Radio-HPLC System

      • Adrian D. Nunn, Alan R. Fritzberg
      Pages 103-124

    3. Overall Radio-HPLC Design

      • Chester A. Mathis, Reese M. Jones, Joseph H. Chasko
      Pages 125-148

    4. Quantitation of Radiolabeled Molecules Separated by High Pressure Liquid Chromatography

      • Michael J. Kessler
      Pages 149-170

    5. Flow Detector Designs: Build Your Own or Buy?

      • Richard D. Hichwa
      Pages 171-179

  4. Applications

    1. Front Matter

      Pages 181-181
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    2. Radio-HPLC: Application to Organics and Metal Chelate Chemistry

      • Alan R. Fritzberg, Adrian D. Nunn
      Pages 183-212

    3. Concepts and Techniques Used in Metabolic Tracer Studies

      • Jorge R. Barrio, Randy E. Keen, Diane C. Chugani, Gerald Bida, Nagichettiar Satyamurthy, Michael E. Phelps
      Pages 213-231

    4. Development of No-Carrier-Added Radiopharmaceuticals with the Aid of Radio-HPLC

      • D. Scott Wilbur
      Pages 233-249

    5. From Cyclotron to Patient via HPLC

      • Michael R. Kilbourn, Michael J. Welch, Carmen S. Dence, Keith R. Lechner
      Pages 251-260

    6. Potential Artifacts in the Chromatography of Radiopharmaceuticals

      • Thomas J. Mangner
      Pages 261-278

    7. HPLC of Radiolabeled Antibodies

      • Donald J. Hnatowich
      Pages 279-293

  5. Back Matter

    Pages 295-300
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Keywords

About this book

In 1906, Michael T. Sweet first developed the chromatographic method by using an adsorbant to separate pigments. Since that time, the technological advances in TLC and HPLC have brought about new definitions of purity in parallel with the advances. Radiopharmaceutical chemistry is especially dependent on the chromat­ ographic technique because of the relatively small amount of material in most radiopharmaceuticals-often so small that the usual physical methods of analytical chemistry cannot be used. As a result, this collection of papers represents the key to successful radiopharmaceutical development by setting the standard for the pres­ of radiochemical purity. ent-day definition William C. Eckelman, Ph.D. Diagnostics Associate Director The Squibb Institute for Medical Research New Brunswick, New Jersey Preface The chapters herein are updated and expanded versions of presentations that the authors made at a symposium held on June 4, 1984 in Los Angeles, California under the sponsorship of the Radiopharmaceutical Science Council of the Society of Nuclear Medicine. All manuscripts were refereed. The intent of the symposium organizers was to enlist participants who work on a day-to-day basis with the analytical and chromatographic techniques to be discussed at the symposium. We feel confident that this distillation of hands-on experience will be of value to graduate students as well as experienced researchers in radio­ pharmaceutical chemistry and related fields which use radiotracer methodology.

Editors and Affiliations

  • Division of Nuclear Medicine Department of Internal Medicine, The University of Michigan, Ann Arbor, USA

    Donald M. Wieland, Michael C. Tobes, Thomas J. Manger

Bibliographic Information

  • Book Title: Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry

  • Editors: Donald M. Wieland, Michael C. Tobes, Thomas J. Manger

  • DOI: https://doi.org/10.1007/978-1-4612-4854-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1986

  • Hardcover ISBN: 978-0-387-96185-9Due: 22 November 1985

  • Softcover ISBN: 978-1-4612-9331-6Published: 01 October 2011

  • eBook ISBN: 978-1-4612-4854-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 300

  • Topics: Pharmacy, Pharmacology/Toxicology

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Pharma

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