Abstract
The discovery that thymus-derived lymphocytes (T cells) were essential for antibody responses but the precursors of the antibody producing cells came from bone marrow lymphocytes (B cells) gave birth to cellular immunology. These observations led to the hypothesis that lymphocytes are composed of functionally distinct subsets of interacting cells. This paradigm was used subsequently to interpret the data that not all T cells were helper T cells. Thus, T cells are now regarded as a heterogeneous collection of cells consisting of regulatory and effector cells. Cytotoxic T cells and cells that mediate delayed hypersensitivity responses are classed as effector T cells. Regulatory T cells that collaborate with B cells and effector T cells are referred to as helper T (Th) cells, whereas those that inhibit responses of other lymphocytes are called suppressor T (Ts) cells. The concerted activities of helper and suppressor T cells provide a highly sophisticated system to finely tune immune responses.
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Kapp, J.A., Sorensen, C.M., Pierce, C.W., Webb, D.R. (1987). Characterization of GAT-Specific Suppressor Factors and Comparison to Other Antigen-Specific Factors. In: Webb, D.R., Pierce, C.W., Cohen, S. (eds) Molecular Basis of Lymphokine Action. Experimental Biology and Medicine, vol 18. Humana Press. https://doi.org/10.1007/978-1-4612-4598-8_4
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DOI: https://doi.org/10.1007/978-1-4612-4598-8_4
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