Molecular Basis of Lymphokine Action

1. Front Matter

   Pages i-xxviii

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2. Keynote Address

   1. Front Matter

      Pages 1-1

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   2. Tumor Growth Factors

      • George J. Todaro

      Pages 3-12

3. Suppressor Factors

   1. Front Matter

      Pages N1-N1

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   2. Suppressor T Cell Receptor and Functional Molecule

      • Masaru Taniguchi, Eiki Matsushita, Kenji Imai, Akihiko Koseki, Takayuki Sumida, Toshitada Takemori et al.

      Pages 13-20

   3. Role of Glycosylation Inhibiting Factor (GIF), a Phospholipase Inhibitory Protein, in the Generation of Antigen-Specific Suppressor T Cells

      • Makoto Iwata, Moriaki Akasaki, Paula Jardieu, Kimishige Ishizaka

      Pages 21-31

   4. Characterization of GAT-Specific Suppressor Factors and Comparison to Other Antigen-Specific Factors

      • Judith A. Kapp, Craig M. Sorensen, Carl W. Pierce, David R. Webb

      Pages 33-46

   5. Soluble Immune Response Suppressor (SIRS) Mediated Inhibition of Cell Division

      • Thomas M. Aune

      Pages 47-58

   6. Differentiation and Proliferation of CD8+ Suppressor T Lymphocytes

      • Robert R. Rich, Edward J. Fox, Medhat N. ElMasry

      Pages 59-71

4. Interleukin 1

   1. Front Matter

      Pages 72-72

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   2. Molecular Studies on Murine Interleukin 1

      • Steven B. Mizel, Jill Suttles, Judith Giri, Jon Lewis, Patricia Kilian, Kathryn A. Paganelli

      Pages 73-81

   3. Multiple Biological Activities of Human Interleukin-1

      • Charles A. Dinarello

      Pages 83-95

   4. A Membrane form of IL-1 — Identification and Control of Expression

      • Emil R. Unanue, Casey T. Weaver, Robert C. Fuhlbrigge, Jeanne-Marie Kiely, David D. Chaplin

      Pages 97-104

   5. Characterization of Interleukin-1 Receptors

      • Steven K. Dower

      Pages 105-116

   6. T Cell Interleukin 1

      • Scott K. Durum, Alison Finnegan, Dan T. Brody, Elizabeth J. Kovacs, Mark R. Smith, Jay A. Berzofsky et al.

      Pages 117-122

5. B Cell Growth and Differentiation Factors

   1. Front Matter

      Pages N2-N2

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   2. Molecular structure and immunological function of human B cell differentiation factor (BSF2)

      • Tadamitsu Kishimoto, Tetsuya Taga, Kiyoshi Yasukawa, Yasuo Watanabe, Tadashi Matsuda, Koichi Nakajima et al.

      Pages 123-136

   3. Current Studies Examining Regulation of the Human B Cell Cycle

      • Julian L. Ambrus Jr., Anthony S. Fauci

      Pages 137-148

   4. Two Types of Mouse Helper T Cell Clone: Differences in B Cell Help and Lymphokine Synthesis

      • Tim R. Mosmann, Holly Cherwinski, Daniel Cher, Robert L. Coffman

      Pages 149-159

6. Interleukin 2

   1. Front Matter

      Pages 160-160

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The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth­ odology were the B-cell growth and differentiation factors, in partic­ ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.

• Activation
• Antigen
• Immunity
• Interleukin 1
• Interleukin-2
• Vivo
• cell division
• genes
• migration
• molecular biology
• proteins
• regulation

• Roche Institute of Molecular Biology, Nutley, USA

  David R. Webb

• Jewish Hospital, Washington University, St. Louis, USA

  Carl W. Pierce

• University of Connecticut, Farmington, USA

  Stanley Cohen

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