Regulatory Polypeptides in the Lympho-Hemopoietic System

  • J. W. Schrader
  • K. B. Leslie
  • I. Clark-Lewis
  • P. Pitha-Rowe
  • H. J. Ziltener
  • B. F. Fazekas
Part of the Experimental Biology and Medicine book series (EBAM, volume 18)

Abstract

Lymphocytes and the other blood and tissue cells derived from the pluri-potential hemopoietic stem cell share not only this common cellular origin, but also many structural and functional properties. One important common property of lympho-hemopoietic cells is the capacity to undergo rapid changes in response to invasion by micro-organisms or other foreign substances. These changes typically include increases in number, localization at sites of pathology, activation of various functions and in many cases are mediated by soluble polypeptide factors. A considerable number of such molecules have now been identified. Some appear to be solely the products of lymphoid cells or of other cells of hemopoietic origin and act as internal regulators of the lynpho-hemopoietic system, whereas others are made by other cell-types eg. epithelial, fibroblasts or endothelial cells. Lymphoid and other cells of hemopoietic origin also produce polypeptides that act outside the lympho-hemopoietic system on epithelial cells, fibroblasts, etc.

Keywords

Migration Carbohydrate Leukemia Fractionation Polypeptide 

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Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • J. W. Schrader
    • 1
    • 2
  • K. B. Leslie
    • 1
    • 2
  • I. Clark-Lewis
    • 1
    • 3
  • P. Pitha-Rowe
    • 2
  • H. J. Ziltener
    • 1
    • 2
  • B. F. Fazekas
    • 2
  1. 1.The Biomedical Research CentreThe University of British ColumbiaVancouverCanada
  2. 2.The Walter and Eliza Hall Institute of Medical ResearchThe Royal Melbourne HospitalAustralia
  3. 3.The California Institute of TechnologyPasadenaUSA

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