Abstract
Recent evidence obtained from mouse T cell clones grown in vitro, has demonstrated that heterogeneity may exist in the helper, or Lyt-1+, L3T4+, Lyt-2-, population of T cells (1,2). We have shown that the patterns of lymphokine synthesis of stimulated T cell clones allow separation of clones into two major groups, synthesizing different sets of lymphokines. There are profound differences in the effector functions of the two types of T cell, mediated, at least in part, by these lymphokines.
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Mosmann, T.R., Cherwinski, H., Cher, D., Coffman, R.L. (1987). Two Types of Mouse Helper T Cell Clone: Differences in B Cell Help and Lymphokine Synthesis. In: Webb, D.R., Pierce, C.W., Cohen, S. (eds) Molecular Basis of Lymphokine Action. Experimental Biology and Medicine, vol 18. Humana Press. https://doi.org/10.1007/978-1-4612-4598-8_14
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DOI: https://doi.org/10.1007/978-1-4612-4598-8_14
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