Abstract
Extensive studies have been done on the factors responsible for the regulation of growth and differentiation of B lymphocytes and the involvement of several distinct factors in the process has been demonstrated (see review 1,2). These factors can be categorized into three groups; i) factors responsible for the activation of resting B cells, ii) factors for the growth and differentiation of activated B cells and iii) factors for the final differentiation of B cells into high-rate Ig-secreting cells. On the basis of the studies done by several investigators, I proposed the three signal model for the differentiation of B cells into antibody secreting cells in a previous review (2); i) anti-Ig or antigen together with BSF1 (IL-4) activate resting B cells at Go stage into G1 phase, ii) activated B cells become responsive to BCGFII which induces proliferation and Ig secretion in activated B cells and iii) BSF2 (BCDF) induces final maturation of B cells into high-rate Ig secreting cells (Fig.1).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Howard, M. and Paul, W.E. Ann. Rev. Immun. 1, 307–333 (1983)
Kishimoto, T. Ann. Rev. Immun. 3, 135–159 (1985)
Noma, Y., Sideras, P., Naito, T., Bergstedt-Lindquist, S., Azuma, C., Severinson, E., Tanabe, T., Kinashi, T., Matsuda, F., Yaoita, Y. and Honjo, T. Nature 319, 640–646 (1986)
Lee, F., Yokota, T., Otsuka, T., Meyerson, P., Villaret, D., Coffman, R., Mosmann, T., Rennick, D., Roehm, N., Smith, C., Zlotnik, A. and Arai, K. Proc. Natl. Acad. Sci. USA. 83, 2061–2065 (1986)
Kinashi, T., Harada, N., Severinson, E., Tanabe, T., Sideras, P., Kinishi, M., Azuma, C., Tominaga, A., Bergstedt-Lindqvist, S., Takahashi, M., Matsuda, F., Yaoita, Y., Takatsu, K. and Honjo T. Nature 324, 70–73 (1986)
Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S., Nakajima, K., Koyama, K., Iwamatsu, A., Tsunasawa, S., Sakiyama, F., Matsui, H., Takahara, Y., Taniguchi, T. and Kishimoto, T. Nature 324, 73–76 (1986)
Hirano, T., Taga, T., Nakano, N., Yasukawa, K., Kashiwamura, S., Shimizu, K., Nakajima, K., Pyun, K.H. and Kishimoto, T. Proc. Natl. Acad. Sci. USA. 82, 5490–5494 (1985)
Sutton, M.G.S.J., Mercier, L., Giuliani, E.R. and Lie, J.T. Mayo clin. Proc. 55, 371–376 (1980)
Weissenbach, J., Chernajovsky, Y., Zeevi, M., Shulman, L., Soreq, H., Nir, U., Wallach, D., Perricaudet, M., Tiollais, P. and Revel, M. Proc. Natl. Acad. Sci. USA. 77, 7152–7156 (1980)
Content, J., De Wit, L., Poupart, P., Opdenakker, G., Van Damme, J. and Billiau, A. Eur. J. Biochem. 152, 253–257 (1985)
Haegeman, G., Content, J., Volckaert, G., Derynck, R., Tavernier, J. and Fiers, W. Eur. J. Biochem. 159, 625–632 (1986)
Kohase, M., Henriksen-DeStefano, D., May, L.T., Vilcek, J. and Sehgal, P.B. Cell 45, 659–666 (1986)
Resnitzky, D., Yarden A., Zipori, D. and Kimchi, A. Cell 46, 31–40 (1986)
Zilberstein, A., Ruggieri, R., Korn, J.H. and Revel, M. EMBO J. 5, 2529–2537 (1986)
Billiau, A. Nature 324, 415–415 (1986)
Rawle, F.C., Shields, J., Smith, S.H., Iliesen, V., Merkenschlager, M., Beverley, P.C.L. and Callard, R.E. Eur. J. Immun. 16, 1017–1019 (1986)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 The Humana Press Inc.
About this chapter
Cite this chapter
Kishimoto, T. et al. (1987). Molecular structure and immunological function of human B cell differentiation factor (BSF2). In: Webb, D.R., Pierce, C.W., Cohen, S. (eds) Molecular Basis of Lymphokine Action. Experimental Biology and Medicine, vol 18. Humana Press. https://doi.org/10.1007/978-1-4612-4598-8_12
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4598-8_12
Publisher Name: Humana Press
Print ISBN: 978-1-4612-8943-2
Online ISBN: 978-1-4612-4598-8
eBook Packages: Springer Book Archive