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T Cell Interleukin 1

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Molecular Basis of Lymphokine Action

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 18))

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Abstract

T cells have generally been regarded as targets for interleukin 1 (IL 1) action. However, we recently observed that the D10.G4.1 T cell clone, widely used as an assay cell for IL 1 (1), produced its own IL 1 following activation by antigen-presenting B cells (2). Here we extend our observations on T cell IL 1: 1) The majority of murine T cell clones produced an IL 1 activity after stimulation 2) This IL 1 activity was neutralized by anti-IL 1-α antibody 3) IL 1 mRNA could be visualized in individual cloned T cells using in situ hybridization 4) Anti-IL 1-α antibody blocked proliferation of antigen-stimulated T cell clones under conditions in which the T cell was the sole IL 1 source.

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References

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Author information

Authors and Affiliations

  1. BRMP, National Cancer Institute Frederick and Bethesda, MD, USA

    Scott K. Durum, Dan T. Brody, Elizabeth J. Kovacs, Mark R. Smith, Howard A. Young & Boris Tartakovsky

  2. IB, National Cancer Institute Frederick and Bethesda, MD, USA

    Alison Finnegan

  3. MB, National Cancer Institute Frederick and Bethesda, MD, USA

    Jay A. Berzofsky

Authors
  1. Scott K. Durum
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  2. Alison Finnegan
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  3. Dan T. Brody
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  4. Elizabeth J. Kovacs
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  5. Mark R. Smith
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  6. Jay A. Berzofsky
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  7. Howard A. Young
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  8. Boris Tartakovsky
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Editor information

Editors and Affiliations

  1. Roche Institute of Molecular Biology, Nutley, New Jersey, USA

    David R. Webb

  2. Jewish Hospital, Washington University, St. Louis, USA

    Carl W. Pierce

  3. University of Connecticut, Farmington, Connecticut, USA

    Stanley Cohen

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© 1987 The Humana Press Inc.

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Durum, S.K. et al. (1987). T Cell Interleukin 1. In: Webb, D.R., Pierce, C.W., Cohen, S. (eds) Molecular Basis of Lymphokine Action. Experimental Biology and Medicine, vol 18. Humana Press. https://doi.org/10.1007/978-1-4612-4598-8_11

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  • DOI: https://doi.org/10.1007/978-1-4612-4598-8_11

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8943-2

  • Online ISBN: 978-1-4612-4598-8

  • eBook Packages: Springer Book Archive

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