Adenosine Receptors as Drug Targets: Fulfilling the Promise?

Williams, M.

doi:10.1007/978-1-4612-3400-5_27

M. Williams

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Abstract

The purine nucleoside, adenosine, has undergone a research renaissance in the past decade fuelled by a more focussed delineation of the A₁ and A₂ receptor types that mediate its actions in mammalian tissues (Hamprecht and Van Calker, 1985). These receptors have a distinct pharmacology and tissue distribution that offer the potential for the development of selective modulators of adenosine related effects that may have use as therapeutic entities (Williams, 1990).

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Laboratory of Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, 20892, USA
Kenneth A. Jacobson PhD
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, 20892, USA
John W. Daly PhD
Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, 20892, USA
Vincent Manganiello MD, PhD

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Williams, M. (1990). Adenosine Receptors as Drug Targets: Fulfilling the Promise?. In: Jacobson, K.A., Daly, J.W., Manganiello, V. (eds) Purines in Cellular Signaling. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3400-5_27

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DOI: https://doi.org/10.1007/978-1-4612-3400-5_27
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