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Regulation of Trophoblast α2-Macroglobulin Receptor/Low-Density Lipoprotein Receptor-Related Protein,: A Multifunctional Receptor Possibly Involved in Trophoblast Invasion and Placental Lipid Transport

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Trophoblast Cells

Part of the book series: Serono Symposia, USA Norwell, Massachusetts ((SERONOSYMP))

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Abstract

The α 2 -macroglobulin receptor (α2MR) or low-densitylipoprotein receptor-related protein (LRP) is a cell-surface receptor synthesized as a 600-kd precursor protein (1, 2). En route to the cell surface, the receptor is processed into 515- and 85-kd subunits. The 85-kd subunit constitutes the membrane-spanning domain of the receptor that noncovalently anchors the 515-kd subunit to the cell surface. The intracellular portion of the 85 kd subunit contains a consensus NP x Y sequence known to be essential for internalization of receptors via coated pits. The 515-kd extracellular subunit has multiple cysteine-rich repeats that are similar to those found in the LDL receptor (3).

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Authors
  1. Mats E. Gåfvels
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  2. George Coukos
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  3. Christos Coutifaris
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  4. Dudley K. Strickland
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  5. Jerome F. Strauss III
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Kansas Medical Center, 66160, Kansas City, KS, USA

    Michael J. Soares Ph.D.

  2. Department of Biology, Sinsheimer Laboratories, University of California, 95064, Santa Cruz, CA, USA

    Frank Talamantes Ph.D.

  3. Division of Endocrinology, Children’s Hospital Medical Center, 45229, Cincinnati, OH, USA

    Stuart Handwerger M.D.

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© 1993 Springer-Verlag New York, Inc.

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Gåfvels, M.E., Coukos, G., Coutifaris, C., Strickland, D.K., Strauss, J.F. (1993). Regulation of Trophoblast α2-Macroglobulin Receptor/Low-Density Lipoprotein Receptor-Related Protein,: A Multifunctional Receptor Possibly Involved in Trophoblast Invasion and Placental Lipid Transport. In: Soares, M.J., Talamantes, F., Handwerger, S. (eds) Trophoblast Cells. Serono Symposia, USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2718-2_8

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  • DOI: https://doi.org/10.1007/978-1-4612-2718-2_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7641-8

  • Online ISBN: 978-1-4612-2718-2

  • eBook Packages: Springer Book Archive

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