Trophoblast Cells

Pathways for Maternal-Embryonic Communication

  • Michael J. Soares
  • Frank Talamantes
  • Stuart Handwerger
Conference proceedings

Part of the Serono Symposia, USA Norwell, Massachusetts book series (SERONOSYMP)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. All in the Family: The Growth Hormone, Prolactin, and Placental Lactogen Triad

  3. Trophoblast Development and Organization

    1. Front Matter
      Pages 11-11
    2. Barry F. King, Thomas N. Blankenship
      Pages 13-30
    3. Michael J. Soares, Teresa N. Faria, Gary P. Hamlin, Xing-Jian Lu, Santanu Deb
      Pages 45-67
  4. Trophoblast-Uterine Interactions

    1. Front Matter
      Pages 69-69
    2. John D. Aplin, Ljiljana Vićovac, Abdul Sattar
      Pages 92-108
    3. Yan Zhou, Caroline H. Damsky, King Chiu, James M. Roberts, Susan J. Fisher
      Pages 109-122
    4. Stuart Handwerger, Randall G. Richards, Susan E. Myers
      Pages 134-150
    5. Y. W. Loke, Ashley King, Gill Chumbley
      Pages 151-159
  5. Biology of Trophoblast Cell Signaling Systems

    1. Front Matter
      Pages 161-161
    2. Frank Talamantes, Masaaki Yamaguchi, Gudmundur Thordarson, Jonathan Southard, Linda Ogren
      Pages 163-168
    3. Mary Lynn Duckworth, May C. Robertson, Ingo C. Schroedter, Claude Szpirer, Henry G. Friesen
      Pages 169-190
    4. Linda A. Schuler, Patricia Scott, Mark A. Kessler
      Pages 191-205
    5. R. Michael Roberts, Douglas W. Leaman, Jose Juan Hernandez-Ledezma, Neal C. Cosby
      Pages 206-221
    6. N. E. Cooke, B. K. Jones, M. Urbanek, A. Misra-Press, A. K. Lee, J. E. Russell et al.
      Pages 222-239
  6. Regulation of Trophoblast Gene Expression

    1. Front Matter
      Pages 241-241

About these proceedings


Trophoblast cells coordinate the activities of maternal and embryonic tissues by secreting hormones, cytokines, and various growth factors that selectively and specifically gain access to maternal and embryonic compartments. Abnormalities associated with trophoblast cell growth, differentiation, or function result in impaired embryonic development. Understanding the complexities of the trophoblast cell signaling system was the focus of the Serono Symposia, USA conference entitled Tropho­ blast Cells: Pathways for Maternal-Embryonic Communication, held August 6-9, 1992, in Las Vegas, Nevada. The conference was designed to provide a forum for morphologists, cell biologists, endocrinologists, and molecular biologists and for scientists investigating primate, ru­ minant, and rodent trophoblast biology. An important outcome of the conference was the communication achieved between basic scientists and clinicians. This volume represents the contributions of the invited symposium speakers. The opening keynote address of the conference was entitled "Chorio­ carcinoma and the Embryo" and was presented by G. Barry Pierce, M. D. , Centennial Distinguished Research Professor of the University of Colorado School of Medicine. The address is not represented in this volume, but deserves a special comment. Dr. Pierce's scientific con­ tributions have significantly influenced our understanding of trophoblast cells. Dr. Pierce, together with Dr. A. Rees Midgley, identified the origin of syncytial trophoblast cells of the primate placenta and discovered that these cells were responsible for the production of chorionic gonadotropin (J Exp Med 1962;115:289-94; Am J Pathol 1963;43:929-43; and Science 1963;141:349-50).


cell embryo genetics hormones molecular genetics placenta regulation tissue

Editors and affiliations

  • Michael J. Soares
    • 1
  • Frank Talamantes
    • 2
  • Stuart Handwerger
    • 3
  1. 1.Department of PhysiologyUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.Department of Biology, Sinsheimer LaboratoriesUniversity of CaliforniaSanta CruzUSA
  3. 3.Division of EndocrinologyChildren’s Hospital Medical CenterCincinnatiUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag New York 1993
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-7641-8
  • Online ISBN 978-1-4612-2718-2
  • About this book
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