Cell Interactions in Trophoblast Invasion

  • John D. Aplin
  • Ljiljana Vićovac
  • Abdul Sattar
Part of the Serono Symposia, USA Norwell, Massachusetts book series (SERONOSYMP)


The extent of trophoblastic penetration of the uterine wall during placentation varies widely between species, but nowhere is it more extensive than in the human (1, 2). Certain pathological conditions of pregnancy show either insufficient (preeclampsia and intrauterine growth retardation) or excessive (placenta percreta) trophoblastic penetration of adjacent maternal tissues and have been suggested to be caused by maternal rather than fetal abnormalities (3, 4). In order to diagnose and treat these pathologies, a greater understanding of the normal control of trophoblast invasion is a necessity. This chapter therefore concentrates on interactions between trophoblast and endometrium in the human, but reference is made to other species where comparison is thought to be instructive. This is most often the case in certain primates and rodents that show interstitial implantation.


Human Placenta Contact Site Decidual Cell BeWo Cell Human Trophoblast 
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© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • John D. Aplin
  • Ljiljana Vićovac
  • Abdul Sattar

There are no affiliations available

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