Trophoblast Cell Differentiation: Expression of the Placental Prolactin Family

  • Michael J. Soares
  • Teresa N. Faria
  • Gary P. Hamlin
  • Xing-Jian Lu
  • Santanu Deb
Part of the Serono Symposia, USA Norwell, Massachusetts book series (SERONOSYMP)


Normal growth and maturation of a specialized extraembryonic structure, the placenta, are essential for the establishment and maintenance of pregnancy. The placenta acts as the interface between maternal and embryonic compartments, developing in parallel with the embryo and facilitating the acquisition of maternal resources required for embryonic and fetal development. This essential responsibility of the placenta is accomplished in a number of important ways, including (i) regulation of the transport of nutrients and wastes, (ii) an immunologic role in preventing fetal rejection, and (iii) an endocrine/communication/signaling role between fetal and maternal compartments. Consequently, understanding the control of placental development is fundamental to an appreciation of the initiation and maintenance of pregnancy and various abnormalities associated with altered growth and development. The cells responsible for these diverse functions of the placenta are trophoblast cells.


Placental Lactogen Trophoblast Giant Cell Trophoblast Cell Line Chorioallantoic Placenta Trophoblast Lineage 
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Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Michael J. Soares
  • Teresa N. Faria
  • Gary P. Hamlin
  • Xing-Jian Lu
  • Santanu Deb

There are no affiliations available

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