Abstract
T cells recognize antigen by virtue of a hetero-dimeric T-cell receptor (TCR) molecule, each chain of which is encoded by several distinct germline gene segments. These variable (V), diversity (D), joining (J), and constant (C) region gene segments rearrange during T-cell ontogeny to give rise to enormous clonal diversity of receptor molecules, each with its own antigen specificity (for a review, see Wilson et al., 1988). A growing number of studies have demonstrated correlations between the expression of particular Vα or Vβ genes, and human T-cell responses to specific antigen/MHC combinations (e.g., Moss et al., 1991; Boitel et al., 1992), superantigens (e.g., Choi et al., 1989; Kappler et al., 1989), or with autoimmune disease susceptibility (e.g., Palliard et al., 1991; Oksenberg et al., 1989).
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© 1994 Springer Science+Business Media New York
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Spinella, D.G., Robertson, J.M. (1994). Analysis of Human T-Cell Repertoires by PCR. In: Mullis, K.B., Ferré, F., Gibbs, R.A. (eds) The Polymerase Chain Reaction. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-0257-8_9
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DOI: https://doi.org/10.1007/978-1-4612-0257-8_9
Publisher Name: Birkhäuser, Boston, MA
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