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Basal Ganglia Circuitry Models of Levodopa-Induced Dyskinesia

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Levodopa-Induced Dyskinesia in Parkinson's Disease

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Abstract

L-3,4-dihydroxyphenylalanine (l-DOPA) treatment in Parkinson’s disease (PD) patients commonly leads to dyskinesia, a hyperkinetic movement disorder that remains an unsolved clinical problem. The unravelling of key pathophysiological mechanisms in PD and dyskinesia has led to updated models of the basal ganglia motor circuit, capturing nonlinear neuronal information processing in a dynamical network architecture. Our understanding into the functional organization of the basal ganglia motor system is further supported by recent computational models that focus on neuronal activations within distinct closed feedback loops. Together, these models of the basal ganglia circuitry compose a more comprehensive and detailed insight into the diverse neuronal dysfunctions in the pathophysiology of PD and LID.

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  1. Department of Neurodegenerative Diseases, Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 146 rue Leo Saignat, Bordeaux, 33076, France

    Wai Kin D. Ko

  2. CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, F-33000, France

    Wai Kin D. Ko, Matthieu Bastide & Erwan Bezard

  3. Department of Neurodegenerative Diseases, Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux, France

    Matthieu Bastide & Erwan Bezard

  4. Motac Neuroscience Ltd, Manchester, UK

    Erwan Bezard

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  1. Wai Kin D. Ko
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Ko, W.K.D., Bastide, M., Bezard, E. (2014). Basal Ganglia Circuitry Models of Levodopa-Induced Dyskinesia. In: Fox, S., Brotchie, J. (eds) Levodopa-Induced Dyskinesia in Parkinson's Disease. Springer, London. https://doi.org/10.1007/978-1-4471-6503-3_7

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