Abstract
The youngest human embryos in which cutaneous development was observed were about 4–5 weeks old. At that point, the embryo’s external surface is covered by the ectoderm, a monolayer of cells stretching over a mesenchymal mantle. It is partially overlaid by the “periderm,” a second layer of bulky elements endowed with microvilli. This situation and ensuing events are presented in Fig. 1.1.
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Zappi, E., Zappi, E.A. (2013). Elements of Cutaneous Embryology, Anatomy, and Biochemistry. In: Dermatopathology. Springer, London. https://doi.org/10.1007/978-1-4471-2894-6_1
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