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The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery

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Characterization of Protein Therapeutics using Mass Spectrometry

Abstract

The search to discover and develop viable therapies for the treatment of diseases continues to branch out in new directions and to improve and incorporate more efficient strategies to identify drug molecules in a cost-effective manner. Although proven treatments such as optimized small molecule drugs continue to provide an effective means for the management of certain medical conditions, alternatives such as engineered protein constructs have also been successful as therapeutic agents for treatment of a variety of diseases. Regardless of the type of drug molecule under consideration, optimized strategies and high-quality quantitative bioanalytical methods must be developed and applied throughout the drug discovery and development process in order to inform critical decisions during the selection and characterization of drug candidates.

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Authors and Affiliations

  1. Bristol-Myers Squibb, Drop code F12-04, Route 206 and Province Line Road, Princeton, NJ, 08543, USA

    Timothy V. Olah, Asoka Ranasinghe, Hongwei Zhang, Richard L. Wong, John Mehl, James Smalley, Steven Wu, Bogdan Sleczka, Yongxin Zhu, Yulia Benitex, Eric Shields & Baomin Xin

  2. Bristol-Myers Squibb, Drop code 4BC-308, 5 Research Parkway, Wallingford, CT, 06492, USA

    Dieter M. Drexler

Authors
  1. Timothy V. Olah
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  2. Asoka Ranasinghe
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  3. Hongwei Zhang
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  4. Richard L. Wong
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  6. Dieter M. Drexler
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  7. James Smalley
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  8. Steven Wu
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  9. Bogdan Sleczka
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  10. Yongxin Zhu
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  13. Baomin Xin
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Correspondence to Timothy V. Olah .

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  1. , Bioanalytical and Discovery Analytical S, Bristol-Myers Squibb, Princeton, 08543, USA

    Guodong Chen

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Olah, T.V. et al. (2013). The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery. In: Chen, G. (eds) Characterization of Protein Therapeutics using Mass Spectrometry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7862-2_3

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