Characterization of Protein Therapeutics using Mass Spectrometry

  • Guodong Chen

Table of contents

  1. Front Matter
    Pages i-x
  2. Ismael Cotte-Rodriguez, Zhixin Miao, Yun Zhang, Hao Chen
    Pages 1-58
  3. Timothy V. Olah, Asoka Ranasinghe, Hongwei Zhang, Richard L. Wong, John Mehl, Dieter M. Drexler et al.
    Pages 95-115
  4. Anthony Tsarbopoulos, Fotini N. Bazoti
    Pages 117-162
  5. Jingjie Mo, Adrienne A. Tymiak, Guodong Chen
    Pages 163-205
  6. Richard Ludwig, Jacob Bongers, Li Tao, Yunping Huang, Jinmei Fu, Wei Wu et al.
    Pages 207-277
  7. Surinder Kaur, Keyang Xu, Ola Saad, Luna Liu, Tim Slattery, Randall Dere
    Pages 279-304
  8. Back Matter
    Pages 403-404

About this book


Protein therapeutics’ high efficacy, safety, and ability to treat life-threatening diseases such as cancer, inflammation and genetic disorders have revolutionized modern medicine. In 2012, 200 companies competed in this $90 billion year industry.


In Characterization of Protein Therapeutics using Mass Spectrometry, expert contributors from academia and industry highlight current approaches and future trends. The book discusses mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies and quantitative approaches. The book also covers various studies involving characterization of process related protein drug impurities/degradants, metabolites, PTMs and  higher order structures of protein therapeutics.


General practitioners in pharmaceutical research, specialists in analytical sciences, and graduate students studying mass spectrometry and pharmaceutical sciences will find this book useful because of  the  step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.


Biologics Drug Discovery Genetics LC/MS MS MS/MS Mass Spectrometry Peptides Protein Protein Characterization Protein therapeutics Protein therapy Proteomics large molecule small molecule

Editors and affiliations

  • Guodong Chen
    • 1
  1. 1., Bioanalytical and Discovery Analytical SBristol-Myers SquibbPrincetonUSA

Bibliographic information

Industry Sectors
Chemical Manufacturing
Consumer Packaged Goods
Oil, Gas & Geosciences