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Classical Hormones Linked to Obesity

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Metabolic Basis of Obesity

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Abstract

Hyperinsulinism, hypercortisolism, hypothyroidism, polycystic ovarian syndrome, and growth hormone deficiency are often associated with obesity. Insulin is a potent anabolic hormone. Treatment with insulin or some antidiabetic drugs results in weight gain through several mechanisms. Insulinoma is a rare cause of hyperinsulinism associated with hypoglycemia, hunger, and rapid weight gain. The etiology of polycystic ovary syndrome (PCOS) is complex and multifactorial. PCOS is often associated with central obesity, insulin resistance, and hyperandrogenemia. Excessive glucocorticoid exposure, such as Cushing’s syndrome, results in central obesity, sarcopenia, osteoporosis, hypertension, and hyperlipidemia.

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Acknowledgments

This work was supported by grants RO1-DK62348 and PO1-DK49210 from the National Institutes of Health.

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  1. Division of Endocrinology, Diabetes and Metabolism, and the Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, 712A Clinical Research Building, Philadelphia, PA, 19104, USA

    Rexford S. Ahima

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  1. Hyeong-Kyu Park
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Correspondence to Rexford S. Ahima .

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  1. School of Medicine, Div. Endocrinology, Diabetes, &, University of Pennsylvania, Curie Blvd. 415, Philadelphia, 19104, Pennsylvania, USA

    Rexford S. Ahima

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Park, HK., Ahima, R.S. (2011). Classical Hormones Linked to Obesity. In: Ahima, R. (eds) Metabolic Basis of Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1607-5_8

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