Metabolic Basis of Obesity

1. Front Matter

   Pages i-xiv

   PDF

2. Principles of Human Energy Metabolism

   • Jose Galgani, Eric Ravussin

   Pages 1-23

3. Intermediary Metabolism of Carbohydrate, Protein, and Fat

   • Keith Tornheim, Neil B. Ruderman

   Pages 25-51

4. Adipose Tissue Development, Structure and Function

   • Jaswinder K. Sethi, Antonio J. Vidal-Puig

   Pages 53-68

5. Adipokines in Health and Disease

   • Rexford S. Ahima, Marcus D. Goncalves

   Pages 69-88

6. Neural Control of Feeding and Energy Homeostasis

   • Emilie Caron, Rexford S. Ahima

   Pages 89-107

7. Gastrointestinal Hormones and Obesity

   • Yan Wang, Efi Kokkotou

   Pages 109-125

8. Genes and Human Obesity

   • R. Arlen Price

   Pages 127-138

9. Classical Hormones Linked to Obesity

   • Hyeong-Kyu Park, Rexford S. Ahima

   Pages 139-154

10. Inflammation and Adipose Dysfunction

    • Rachana Shah, Muredach P. Reilly

    Pages 155-173

11. Insulin Resistance in the Metabolic Syndrome

    • Sudha B. Biddinger, Brice Emanuelli

    Pages 175-198

12. Pancreatic Islet β-Cell Failure in Obesity

    • Tomoaki Morioka, Rohit N. Kulkarni

    Pages 199-217

13. Non-Alcoholic Fatty Liver Disease and the Metabolic Syndrome

    • Sonia M. Najjar

    Pages 219-227

14. Sleep, Circadian Rhythms and Metabolism

    • Eleonore Maury, Kathryn Moynihan Ramsey, Joseph Bass

    Pages 229-255

15. Obesity and Cardiac Dysfunction

    • Gary Sweeney, Sheldon E. Litwin, Evan Dale Abel

    Pages 257-292

16. Atherogenic Lipid Metabolism in Obesity

    • Sue-Anne Toh, Michael Levin, Daniel J. Rader

    Pages 293-309

17. Gut Microbes, Immunity, and Metabolism

    • Evelyn Hsu, Gary Wu

    Pages 311-330

18. Impact of Obesity on Female Reproductive Health

    • Moshood O. Olatinwo, Djana Harp, Winston Thompson, Hyeong-Kyu Park, Roland Mathews

    Pages 331-341

19. Lessons from HIV Lipodystrophy and Drug-Induced Metabolic Dysfunction

    • Steven Grinspoon

    Pages 343-358

20. Principles of Obesity Therapy

    • Rexford S. Ahima

    Pages 359-379

The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.

• Adipokines
• Adipose tissue
• Cardiac dysfunction
• Circadian rhythms
• Energy metabolism
• Female reproductive health
• Gastrointestinal hormones
• Genetics
• Hormones
• Insulin
• Lipodystrophy
• Metabolism
• Neural control
• Obesity
• Pancreatic beta cells

From the reviews:

“This book presents in-depth reviews on a wide variety of topics related to the metabolic basis of obesity. … The book is written for researchers, clinicians, students, and the public at large. … it is most appropriate for researchers and clinicians who focus on patients with metabolic disorders. … This is a great book on the metabolic basis of obesity. It is a fantastic place to start for researchers and clinicians who wish to obtain a deeper understanding of this timely and important area.” (Ronald N. Cohen, Doody’s Review Service, April, 2011)

• School of Medicine, Div. Endocrinology, Diabetes, &, University of Pennsylvania, Philadelphia, USA

  Rexford S. Ahima

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