The history of the role of hematopoietic growth factors (HGFs) in the regulation of hematopoiesis is briefly reviewed, commencing with the studies that defined the hematopoietic stem cell and led to the development of in vitro assays for HGFs. The nature of HGF synergism and the underlying mechanisms, as well as the “permissive” versus “instructive” models of HGF action, are also discussed. In addition, work on one of the HGFs, colony stimulating factor-1 (CSF-1), is reviewed, including its function in development as revealed by studies of mouse mutants and its role in innate immunity, inflammatory disease and cancer.
Keywords: blood cells, macrophages, osteoclasts, review, CSF-1
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer
About this paper
Cite this paper
Stanley, E.R. (2008). Regulation of Hematopoiesis by Growth Factors. In: Bilko, N.M., Fehse, B., Ostertag, W., Stocking, C., Zander, A.R. (eds) Stem Cells and their Potential for Clinical Application. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6469-2_5
Download citation
DOI: https://doi.org/10.1007/978-1-4020-6469-2_5
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-6467-8
Online ISBN: 978-1-4020-6469-2
eBook Packages: MedicineMedicine (R0)