Stem Cells and Their Potential for Clinical Application

1. Front Matter

   Pages i-xv

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2. Haematopoietic Stem Cells And Haematopoiesis

   1. Clonal Dominance after Reconstitution of the Haematopoietic System with Bone Marrow Cells Retroviral

      • Gottfried von Keudell, Kerstin Cornils, Anita Badbaran, Claudia Lange, Boris Fehse

      Pages 1-15

   2. Function of the Membrane-Bound Isoform Ligands of the Receptor Tyrosine Kinase Subclass III in Inducing Inducing Self-Renewal of Early Hematopoietic Progenitor Cells

      • Jutta Friel, Christoph Heberlein, Maren Geldmacher, Wolfram Ostertag

      Pages 17-44

   3. Functional and Phenotypic Heterogeneity of the Human Hematopoietic Stem Cell (HSC) Compartment

      • Olga I. Gan, Joby L. Mckenzie, Monica Doedens, John E. Dick

      Pages 45-53

   4. Alterations of Frequency of Hematopoietic Precursors in Mice Subjected to Multiple Courses of Low-Dose G-CSF Injections

      • Irina N. Nifontova, Daria A. Svinareva, Joseph L. Chertkov, Valerii G. Savchenko, Nina J. Drize

      Pages 55-62

   5. Regulation of Hematopoiesis by Growth Factors

      • E. Richard Stanley

      Pages 63-75

3. Biology Of Non-Haematopoietic Stem Cells

   1. Stem Cell Technologies in Gerontological Research

      • Gennadij M. Butenko

      Pages 77-82

   2. Osteopetrotic Models for Identifying Genes that Control Bone Resorption

      • Wieslaw Wiktor-Jedrzejczak

      Pages 83-104

   3. Non-Hematopoietic Bone Marrow Cells for Regenerative Medicine

      • Claudia Lange, Florian Tögel, Kai Jaquet, Harald Ittrich, Christoph Westenfelder, Axel R. Zander

      Pages 105-121

   4. Epithelial Plasticity of Hepatocytes During Liver Tumor Progression

      • Mario Mikula, Christian Lahsnig, Alexandra N. M. Fischer, Verena Proell, Heidemarie Huber, Eva Fuchs et al.

      Pages 123-135

   5. Blood Vessels as a Source of Progenitor Cells in Human Embryonic and Adult Life

      • Mihaela Crisan, Bo Zheng, Elias T. Zambidis, Solomon Yap, Manuela Tavian, Bin Sun et al.

      Pages 137-147

4. Stem Cells And Malignancy

   1. Stem Cells and Leukaemia

      • Volodymyr Bebeshko, Dimitry Bazyka

      Pages 149-161

   2. Telomere and Stem Cell Biology in Chronic Myeloid Leukemia

      • Stefan Balabanov, Ute Brassat, Mirja Bernhard, Viola Kob, Artur Gontarewicz, Tim H. Brümmendorf

      Pages 163-169

   3. Potential Immune Escape Mechanisms of Tumors: MHC Class I Molecules – Enemies or Friends

      • Barbara Seliger

      Pages 171-181

   4. The RUNX1 Transcription Factor: A Gatekeeper in Acute Leukemia

      • Carol Stocking, Birte Niebuhr, Meike Fischer, Maike Täger, Jörg Cammenga

      Pages 183-199

5. Cell Processing, Expansion and Genetic Modification

   1. Novel Methodological Approaches in Assessment and Enrichment of Stem Cell Population

      • Nadja M. Bilko, Dennis I. Bilko

      Pages 201-210

   2. Animal Hybrids and Stem Cells: Their Use in Biotechnology and Clinical Practice

      • Lev P. Djakonov

      Pages 211-222

   3. Cryopreservation of Stem Cells

      • Valentin I. Grischenko, Lubov A. Babiychik, Alexander Yu. Petrenko

      Pages 223-231

   4. The M813 Retrovirus belongs to a Unique Interference Group and is Highly Fusogenic

      • Vladimir Prassolov, Sibyll Hein, Dmitry Ivanov, Jürgen Löhler, Carol Stocking, Pavel Spirin

      Pages 233-244

   5. Reconstructing an Anti-Tumor Immune Repertoire for Targeted AML Therapy

      • Matthias Theobald

      Pages 245-251

This publication was initiated on the occasion of the NATO-Advanced Study Institute (ASI) meeting “Stem Cells and their potential for clinical application” which took place from August 23 – 25, 2006 in Kyiv and from August 26 – 31, 2006 in Simeiz, Ukraine. The meeting was devoted to “hot topics” in Stem cell research such as Regulation of Haematopoietic and Non-haematopoietic Stem Cells, Clinical Application of Stem Cells, Preclinical Models and Gene Therapy. The editors are pleased that the original idea of a book could eventually be realised. This was made possible because of the willingness of many meeting participants to saddle themselves with the additional work of compiling their data and thoughts in form of an article for this edition. We are thus foremost grateful to all contributors for their valuable input. In accordance with the conference’s main topics, the book is divided into five chapters - “Haematopoietic stem cells and haematopoiesis”, “Biology of n- haematopoietic stem cells”, “Stem cells and malignancy”, “Cell processing; expansion and genetic modification” and “Clinical haematopoietic stem cell transplantation”.

• Biology
• Chemistry
• NATO
• Science
• Security
• Sub-Series A
• Telomere
• Transplantation
• cryopreservation
• gene therapy
• regulation

• National University “Kiev-Mohyla- Academy”, Ukaraine

  Nadja M. Bilko

• Universitätsklinikum Hamburg-Eppendorf Onkologisches Zentrum, Germany

  Boris Fehse, Axel R. Zander

• Hannover Medical School, Germany

  Wolfram Ostertag

• Heinrich-Pette-Institute for Experimental Virology and Immunology, Germany

  Carol Stocking

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