Blood Vessels as a Source of Progenitor Cells in Human Embryonic and Adult Life

  • Mihaela Crisan
  • Bo Zheng
  • Elias T. Zambidis
  • Solomon Yap
  • Manuela Tavian
  • Bin Sun
  • Jean-Paul Giacobino
  • Louis Casteilla
  • Johnny Huard
  • Bruno Péault
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)

Recent experimental results in culture and in vivo are summarized that show the existence of developmental relationships between cells that build up blood vessel walls and some previously unrelated tissues and organs. It was formerly demonstrated, in lower vertebrates as well as mammals, including humans, that discrete subsets of blood-forming endothelial cells play a key role in the emergence of the definitive hematopoietic system. We have also documented the existence in human skeletal muscle of endothelium-borne, extremely potent myogenic progenitor cells. Finally, we have characterized and purified perivascular cells – or pericytes – from human tissues and demonstrated their ability to give rise to mesodermal differentiated derivatives, principally skeletal muscle.

Keywords: Endothelial cell; pericyte; stem cell; blood vessel; skeletal muscle

Keywords

Leukemia Dexamethasone Sorting CD117 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer 2008

Authors and Affiliations

  • Mihaela Crisan
    • 1
  • Bo Zheng
    • 1
  • Elias T. Zambidis
    • 2
  • Solomon Yap
    • 1
  • Manuela Tavian
    • 3
  • Bin Sun
    • 1
  • Jean-Paul Giacobino
    • 1
  • Louis Casteilla
    • 1
  • Johnny Huard
    • 1
  • Bruno Péault
    • 4
  1. 1.Stem Cell Research CenterChildren's Hospital of PittsburghPittsburghUSA
  2. 2.Divisions of Immunology and Hematopoiesis, Pediatric OncologyJohns Hopkins UniversityBaltimoreUSA
  3. 3.INSERM U506, Hopital Paul BrousseFrance
  4. 4.Rangos Research CenterChildren's Hospital of PittsburghPittsburghUSA

Personalised recommendations