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Drug Absorption and Routes of Administration

  • Chapter
Physicochemical Principles of Pharmacy

Abstract

This chapter provides basic information on the mechanisms of drug absorption and how the processes of absorption are affected by the properties of the drug and its formulation, by its interaction with the aqueous phase and by the nature of the membrane. Oral absorption is discussed in some detail and the influence of the following should become clear: the extent and rate of dissolution of the drug, the rate of gastric emptying, the site of absorption. The pH of the contents of the gastrointestinal tract (gut) and the effect of pH on the ionisation of the drug (discussed also in section 5.2.3) are crucial.

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Author information

Authors and Affiliations

  1. The School of Pharmacy, University of London, UK

    A. T. Florence

  2. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK

    D. Attwood

Authors
  1. A. T. Florence
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  2. D. Attwood
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© 1998 A. T. Florence and D. Attwood

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Florence, A.T., Attwood, D. (1998). Drug Absorption and Routes of Administration. In: Physicochemical Principles of Pharmacy. Palgrave, London. https://doi.org/10.1007/978-1-349-14416-7_10

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  • DOI: https://doi.org/10.1007/978-1-349-14416-7_10

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-0-333-69081-9

  • Online ISBN: 978-1-349-14416-7

  • eBook Packages: EngineeringEngineering (R0)

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