Abstract
Phencyclidine (PCP), at low doses (0.3–3 mg/kg), selectively delayed the onset or prevented the occurrence of pentylenetetrazol (PTZ)-induced tonic, but not clonic seizures. However, at a dose of 10 mg/kg it acted as a convulsant agent (Hayes and Balster, 1985). PCP-like drugs, when evaluated with respect to potential anti/pro-convulsant actions, demonstrated only anticonvulsant properties. Modulation of the N-methyl-D-aspartate (NMDA) receptor site by PCP and PCP-like compounds as a mechanism of anticonvulsant activity has been suggested by Leander et al. (1988), in which a strong correlation was demonstrated between the anticonvulsant activity of PCP/PCP-like compounds and the minimal effective dose which blocks NMDA receptor-mediated NMDA-induced lethality.
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References
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Lipovac, M.N. et al. (1992). Anticonvulsant Effects of Phencyclidine and PCP-like Drugs on Audiogenic Seizures Induced by Metaphit in Mice. In: Segal, M.B. (eds) Barriers and Fluids of the Eye and Brain. Palgrave, London. https://doi.org/10.1007/978-1-349-12306-3_17
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DOI: https://doi.org/10.1007/978-1-349-12306-3_17
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-12308-7
Online ISBN: 978-1-349-12306-3
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