Barriers and Fluids of the Eye and Brain

1. Front Matter

   Pages i-xxix

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2. Membrane Transport in Ocular Epithelia

   • J. A. Zadunaisky

   Pages 1-13

3. Transport Functions of the Blood—Ocular and Blood—Brain Barriers, and the Microenvironment of Neuronal and non-neuronal Tissues

   • Laszlo Z. Bito

   Pages 14-23

4. Ocular Pulsatile Blood Flow in Healthy and Diabetic Eyes

   • Maurice E. Langham

   Pages 24-29

5. Physiology of the Vitreous: A Personal View

   • D. M. Maurice

   Pages 30-36

6. Role of Carbonic Anhydrase in Aqueous Humour and Cerebrospinal Fluid Formation

   • Thomas H. Maren

   Pages 37-48

7. Pharmacological Manipulation of Cerebrospinal Fluid Secretion

   • Michael Pollay

   Pages 49-58

8. Structural, Ultrastructural and Functional Correlations among Local Capillary Systems within the Brain

   • Joseph Fenstermacher, Hiroyuki Nakata, Atsushi Tajima, Mao-Hsiung Yen, Virgil Acuff, Kurt Gruber

   Pages 59-71

9. Effects of Phenylephrine and Dopamine on Locomotor Activity and Permeability of the Blood-Brain Barrier of Mice Exposed to Lead from Birth

   • Floyd R. Domer

   Pages 72-81

10. Mechanisms Regulating Peptide Levels in the Cerebrospinal Fluid

    • David J. Begley, Daniel G. Chain

    Pages 82-105

11. Blood—Brain Barrier Permeability to Peptides and Proteins

    • Berislav V. Zloković, J. Gordon McComb, Malcolm B. Segal, Hugh Davson

    Pages 106-115

12. Drainage of Cerebrospinal Fluid During Development and in Congenital Hydrocephalus

    • Hazel C. Jones

    Pages 116-127

13. Development of the Blood—Brain Barrier to Macromolecules

    • N. R. Saunders

    Pages 128-155

14. Pathophysiology of Communicating Hydrocephalus: Information Provided by the New Imaging Modalities

    • A. Everette James Jr., Christine H. Lorenz, James A. McKanna, Jeff L. Creasy, C. Leon Partain, Ernst-Peter Strecker et al.

    Pages 156-183

15. Opening of the Blood—Brain Barrier to D-Mannitol Induced by Sensorimotor Cortical Lesions in the Anaesthetized Guinea-pig

    • Lj. M. Rakić, B. V. Zloković, Jasmina B. Mačkić, M. N. Lipovac, D. M. Mitrović, R. Veskov et al.

    Pages 184-187

16. Uptake of Thiamine by the Isolated Perfused Sheep Choroid Plexus

    • Dushka M. Mitrović, M. B. Segal, J. E. Preston, H. Davson, B. V. Zloković

    Pages 188-191

17. Epileptogenic Activity of Metaphitinduced Audiogenic Seizure in Small Rodents

    • Milo N. Lipovac, V. Susić, B. V. Zloković, A. E. Jacobson, K. C. Rice, A. N. Popović et al.

    Pages 192-197

18. Anticonvulsant Effects of Phencyclidine and PCP-like Drugs on Audiogenic Seizures Induced by Metaphit in Mice

    • Milo N. Lipovac, E. A. Debler, A. Lajtha, B. V. Zloković, A. E. Jacobson, K. C. Rice et al.

    Pages 198-202

19. Cotransport of Sodium, Potassium and Chloride in the Isolated Choroid Plexus

    • C. Johanson, J. Parmelee, D. Bairamian, S. Sweeney, M. Epstein

    Pages 203-207

20. Effect of Congenital Hydrocephalus on Cortical Structure in the H-Tx Rat

    • R. M. Bucknalls, N. G. Harriss, H. C. Jones

    Pages 208-209

This book describes the latest findings on the control of the fluid environment of the eye and the brain. The eye is considered from its multiple interfaces. Carbonic anhydrase, which forms a bridge between the eye and CSF, and the secretion and development of its drainage is reviewed. The blood-brain barrier is considered from the cerebral capillary, and recent findings with homologous molecules refute the earlier studies with 'foreign' tracers. A final chapter gives a fascinating glimpse of the future with a description of the latest imaging techniques used in neurological diagnosis.

• pathophysiology
• pharmacology
• physiology
• protein
• tissue

• Sherrington School of Physiology, UMDS Guy’s and St Thomas’s Hospitals, London, UK

  Malcolm B. Segal

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