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Overview and Clinical Applications of VEGF-A

  • Chapter
Angiogenesis

Vascular endothelial growth factor (VEGF)-A is an endothelial cell-specific mitogen and an angiogenic inducer. Two tyrosine kinases, VEGFR1 and VEGFR-2, are VEGF receptors. Loss of a single VEGF-A allele results in defective vascularization and embryonic lethality. Anti-VEGF-A monoclonal antibodies or other VEGF inhibitors block growth and neovascularization in tumor models. We developed a humanized anti- VEGF-A monoclonal antibody (bevacizumab). Bevacizumab demonstrated clinical efficacy, including a survival advantage, in multiple tumor types. Bevacizumab has been approved by the FDA for the treatment of previously untreated and relapsed metastatic colorectal cancer, non-small-cell lung cancer, and previously untreated metastatic breast cancer, in combination with chemotherapy. Also, two small molecule inhibitors of VEGF receptor tyrosine kinase activity have been approved by the FDA for the treatment of metastatic renal cell carcinoma. Furthermore, VEGF-A is implicated in intraocular neovascularization associated with active proliferative retinopathies and the wet form of age-related macular degeneration (AMD). A humanized anti- VEGF-A Fab (ranibizumab) has been developed for the treatment of the neovascular form of AMD. Ranibizumab administration maintained and even improved visual acuity and was approved by the FDA for the treatment of AMD in June 2006.

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Authors and Affiliations

  1. Genentech, Inc., 94080, San Francisco, CA, USA

    Napoleone Ferrara

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  1. Napoleone Ferrara
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  1. Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    William D. Figg

  2. Department of Surgery Harvard Medical School and Vascular Biology Program, Children's Hospital Boston, Boston, MA, USA

    Judah Folkman

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© 2008 Springer Science+Business Media, LLC

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Ferrara, N. (2008). Overview and Clinical Applications of VEGF-A. In: Figg, W.D., Folkman, J. (eds) Angiogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-71518-6_30

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  • DOI: https://doi.org/10.1007/978-0-387-71518-6_30

  • Publisher Name: Springer, Boston, MA

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