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Tissue Engineered Myocardium

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Myocardial Tissue Engineering

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 6))

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Abstract

Myocardial tissue engineering is equally attractive for basic and translational cardiovascular research as it may ultimately provide “realistic” in vitro heart muscle models and therapeutic myocardial substitutes. A prerequisite for successful cardiac muscle engineering is simulation of natural cardiomyogenesis in vitro to yield true myocardial structures with appropriate macro- and micro-morphology as well as function. This requires an assembly of the various cellular and extracellular components of the living heart under so called biomimetic culture conditions. This chapter will give an introduction into different tissue engineering modalities and discuss essential cellular and extracellular components as well as other biomimetic factors, controlling myocardial assembly in vitro. Finally, potential in vitro and in vivo applications such as modeling of heart muscle development, applications in functional genomics and disease modeling, drug development and safety assessment as well as cardiac repair will be reviewed.

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Acknowledgments

WHZ is supported by the German Research Council (Zi 708/7–1, 8–1, 10–1), the Federal Ministry of Science and Education (DLR FKZ: 01GN0827 and 01GN0957), and the European Union (EU FP7 CARE-MI).

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  1. Department of Pharmacology, Heart Research Center Göttingen, Georg-August University Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    Wolfram-Hubertus Zimmermann

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Correspondence to Wolfram-Hubertus Zimmermann .

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  1. University of Erlangen-Nuremberg, Department of Materials Science and Engi, Institute of Biomaterials, Erlangen, 91058, Germany

    Aldo R. Boccaccini

  2. South Kensington Campus, Imperial College London, London, SW7 2AZ, United Kingdom

    Sian E. Harding

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Zimmermann, WH. (2010). Tissue Engineered Myocardium. In: Boccaccini, A., Harding, S. (eds) Myocardial Tissue Engineering. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2010_41

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