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Myocardial Tissue Engineering

  • Aldo R. Boccaccini
  • Sian E. Harding

Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 6)

Table of contents

  1. Front Matter
    Pages i-x
  2. Roberto Gaetani, Pieter A. F. Doevendans, Elisa Messina, Joost P. G. Sluijter
    Pages 1-27
  3. Paolo Di Nardo, Marilena Minieri, Annalisa Tirella, Giancarlo Forte, Arti Ahluwalia
    Pages 29-47
  4. Payam Akhyari, Mareike Barth, Hug Aubin, Artur Lichtenberg
    Pages 49-79
  5. Wolfram-Hubertus Zimmermann
    Pages 111-132
  6. Jennifer M. Singelyn, Karen L. Christman
    Pages 133-163
  7. Marie Noëlle Giraud, Hendrik Tevaearai
    Pages 165-185
  8. Jorge A. Genovese, Cristiano Spadaccio, Alberto Rainer, Elvio Covino
    Pages 215-242
  9. Adrian H. Chester, Magdi H. Yacoub, Patricia M. Taylor
    Pages 243-266
  10. Back Matter
    Pages 267-268

About this book

Introduction

Myocardial tissue engineering (MTE), a strategy that uses materials or material/cell constructs to prolong patients’ life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered ‘vehicle’, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book also considers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.

Keywords

Embrionic Stem Cells cardiac cells Heart Mechanical Capability Mechnical Compatibility Pluripotent Stem Cells

Editors and affiliations

  • Aldo R. Boccaccini
    • 1
  • Sian E. Harding
    • 2
  1. 1.University of Erlangen-Nuremberg, Department of Materials Science and EngiInstitute of BiomaterialsErlangenGermany
  2. 2.South Kensington CampusImperial College LondonLondonUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-18056-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Engineering
  • Print ISBN 978-3-642-18055-2
  • Online ISBN 978-3-642-18056-9
  • Series Print ISSN 1868-2006
  • Series Online ISSN 1868-2014
  • Buy this book on publisher's site
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