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The Cell Biology of Mitotic Recombination in Saccharomyces Cerevisiae

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Molecular Genetics of Recombination

Part of the book series: Topics in Current Genetics ((TCG,volume 17))

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Abstract

Genetic recombination relies on a number of biochemical activities that must be present at the right time and place in order for two DNA molecules to be recombined properly. Recent advances in real-time fluorescence microscopy provide us with a glimpse of homologous recombination taking place in living cells. These approaches reveal that homologous recombination is highly choreographed in vivo with its spatio-temporal organization being dependent on both cell cycle phase and the nature of the initiating DNA lesion. In this chapter, we review the cell biology of homologous recombination in mitotic cells with the main focus on the yeast Saccharomyces cerevisiae but also drawing parallels to other eukaryotic organisms.

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Authors and Affiliations

  1. Department of Genetics, Institute of Molecular Biology and Physiology, University of Copenhagen, Øster Farimagsgade 2A, 1353, Copenhagen K, Denmark

    Michael Lisby

  2. Department of Genetics & Development, Columbia University Medical Center, 701 West 168th Street, 10032, New York, NY, USA

    Rodney Rothstein

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  1. Michael Lisby
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  2. Rodney Rothstein
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Correspondence to Michael Lisby or Rodney Rothstein .

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Andrés Aguilera Rodney Rothstein

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© 2006 Springer-Verlag Berlin Heidelberg

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Lisby, M., Rothstein, R. (2006). The Cell Biology of Mitotic Recombination in Saccharomyces Cerevisiae . In: Aguilera, A., Rothstein, R. (eds) Molecular Genetics of Recombination. Topics in Current Genetics, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_2006_0212

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